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Gene Review

gcm2  -  glial cells missing homolog 2 (Drosophila)

Danio rerio

Synonyms: GCMb, Gcm-2, SO:0000704
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High impact information on gcm2

  • Strikingly, zebrafish gcm2 is expressed in the ectodermal portion of the pharyngeal epithelium and is required for the development of the gill filament buds, precursors of fish-specific gill filaments [1].
  • This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies [1].
  • Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm [1].
  • However, in the absence of Fgfrl1a, larvae fail to express the transcription factor glial cells missing 2 (gcm2), a gene necessary for cartilage and gill filament formation, in the ectodermal lining of the branchial arches [2].


  1. Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Hogan, B.M., Hunter, M.P., Oates, A.C., Crowhurst, M.O., Hall, N.E., Heath, J.K., Prince, V.E., Lieschke, G.J. Dev. Biol. (2004) [Pubmed]
  2. An essential role for zebrafish Fgfrl1 during gill cartilage development. Hall, C., Flores, M.V., Murison, G., Crosier, K., Crosier, P. Mech. Dev. (2006) [Pubmed]
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