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Gene Review

gcm2  -  glial cells missing homolog 2 (Drosophila)

Danio rerio

Synonyms: GCMb, Gcm-2, SO:0000704
 
 
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High impact information on gcm2

  • Strikingly, zebrafish gcm2 is expressed in the ectodermal portion of the pharyngeal epithelium and is required for the development of the gill filament buds, precursors of fish-specific gill filaments [1].
  • This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies [1].
  • Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm [1].
  • However, in the absence of Fgfrl1a, larvae fail to express the transcription factor glial cells missing 2 (gcm2), a gene necessary for cartilage and gill filament formation, in the ectodermal lining of the branchial arches [2].

References

  1. Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Hogan, B.M., Hunter, M.P., Oates, A.C., Crowhurst, M.O., Hall, N.E., Heath, J.K., Prince, V.E., Lieschke, G.J. Dev. Biol. (2004) [Pubmed]
  2. An essential role for zebrafish Fgfrl1 during gill cartilage development. Hall, C., Flores, M.V., Murison, G., Crosier, K., Crosier, P. Mech. Dev. (2006) [Pubmed]
 
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