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Gene Review:

Fer2LCH - Ferritin 2 light chain homologue

Drosophila melanogaster

Synonyms: 2LCH, CG1469, Dmel\CG1469, Fer-H, Fer2LC, ...

Charlesworth, A. et al., Dunkov, B.C. et al., Georgieva, T. et al.

Dunkov, Georgieva,

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High impact information on Fer2LCH

The deduced amino acid sequence of the D. melanogaster ferritin subunit contained a signal sequence and resembled most closely ferritin of the mosquito Aedes aegypti [1].
Conserved ferritin PCR primers were used to amplify a 360-bp cDNA product, which was used to isolate a clone from a D. melanogaster cDNA library that contained the complete coding sequence for a ferritin subunit [1].
Western blotting reveals that LCH is the predominant ferritin subunit in all life stages [2].

Biological context of Fer2LCH

These genes, located at position 99F1, have different exon-intron structures (Fer1HCH has three introns and Fer2LCH has two introns) and are divergently transcribed [3].

References

Isolation and properties of Drosophila melanogaster ferritin--molecular cloning of a cDNA that encodes one subunit, and localization of the gene on the third chromosome. Charlesworth, A., Georgieva, T., Gospodov, I., Law, J.H., Dunkov, B.C., Ralcheva, N., Barillas-Mury, C., Ralchev, K., Kafatos, F.C. Eur. J. Biochem. (1997) [Pubmed]
Drosophila melanogaster ferritin: cDNA encoding a light chain homologue, temporal and tissue specific expression of both subunit types. Georgieva, T., Dunkov, B.C., Dimov, S., Ralchev, K., Law, J.H. Insect Biochem. Mol. Biol. (2002) [Pubmed]
Organization of the ferritin genes in Drosophila melanogaster. Dunkov, B.C., Georgieva, T. DNA Cell Biol. (1999) [Pubmed]

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