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Gene Review

Fer1HCH  -  Ferritin 1 heavy chain homologue

Drosophila melanogaster

Synonyms: 1HCH, BEST:LD36673, CG2216, Dmel\CG2216, FER1, ...
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Disease relevance of Fer1HCH

  • Synthesis of ferritin HCH subunit mRNAs that lack an IRE may be important under conditions of iron overload [1].
  • Changes in toxicity of the individual isomer solutions were considered to be due, in part, to interconversions of HCH isomers [2].

High impact information on Fer1HCH

  • This ferritin contains a putative mitochondrial targeting sequence and an epitope-tagged version localizes to mitochondria in transfected cells [3].
  • In parallel with the differential larval and adult phenotypes, our results indicate that dfh silencing differentially dysregulates ferritin expression in adults but not in larvae [4].
  • Proteins whose levels increase after clotting include a ferritin-subunit and two members of the immunoglobulin family with a high similarity to the small immunoglobulin-like molecules involved in mammalian innate immunity [5].
  • Drosophila ferritin mRNA: alternative RNA splicing regulates the presence of the iron-responsive element [6].
  • The deduced amino acid sequence of the D. melanogaster ferritin subunit contained a signal sequence and resembled most closely ferritin of the mosquito Aedes aegypti [7].

Biological context of Fer1HCH

  • These genes, located at position 99F1, have different exon-intron structures (Fer1HCH has three introns and Fer2LCH has two introns) and are divergently transcribed [8].
  • The structure of two other invertebrate ferritin genes, from the nematode Caenorhabditis elegans (located on chromosomes I and V), was also analyzed [8].
  • When Northern blots were probed with a HCH cDNA, two bands were observed, representing at least two messages of different sizes that result from the choice of two different polyadenylation sites [9].
  • Conserved ferritin PCR primers were used to amplify a 360-bp cDNA product, which was used to isolate a clone from a D. melanogaster cDNA library that contained the complete coding sequence for a ferritin subunit [7].
  • Dynamic acylation of ferritin may slow but not prevent its passage out of the ER [10].

Anatomical context of Fer1HCH

  • At pupariation, ferritin becomes more abundant in hemolymph than in other tissues [11].
  • Northern blot analysis indicated that there were 1.5- and 1.75-fold increases in the expression of ferritin mRNA after iron-fed fat body and midgut, respectively [12].
  • Also, we confirmed that the ferritin mRNA is not expressed in adult ovary and testis [12].

Associations of Fer1HCH with chemical compounds

  • On polyacrylamide gel electrophoresis, the product showed two protein bands corresponding to the ferritin monomer and dimer [7].
  • Insect messenger RNAs for ferritin and succinate dehydrogenase subunit b have IREs that are active translational control sites [13].

Other interactions of Fer1HCH


Analytical, diagnostic and therapeutic context of Fer1HCH


  1. Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster. Georgieva, T., Dunkov, B.C., Harizanova, N., Ralchev, K., Law, J.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Interconversions and toxicity changes in hexachlorocyclohexane isomers on dispersion in water. Deo, P.G., Hasan, S.B., Majumder, S.K. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1981) [Pubmed]
  3. Characterization of mitochondrial ferritin in Drosophila. Missirlis, F., Holmberg, S., Georgieva, T., Dunkov, B.C., Rouault, T.A., Law, J.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila. Anderson, P.R., Kirby, K., Hilliker, A.J., Phillips, J.P. Hum. Mol. Genet. (2005) [Pubmed]
  5. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson, C., Korayem, A.M., Scherfer, C., Loseva, O., Dushay, M.S., Theopold, U. J. Biol. Chem. (2004) [Pubmed]
  6. Drosophila ferritin mRNA: alternative RNA splicing regulates the presence of the iron-responsive element. Lind, M.I., Ekengren, S., Melefors, O., Söderhäll, K. FEBS Lett. (1998) [Pubmed]
  7. Isolation and properties of Drosophila melanogaster ferritin--molecular cloning of a cDNA that encodes one subunit, and localization of the gene on the third chromosome. Charlesworth, A., Georgieva, T., Gospodov, I., Law, J.H., Dunkov, B.C., Ralcheva, N., Barillas-Mury, C., Ralchev, K., Kafatos, F.C. Eur. J. Biochem. (1997) [Pubmed]
  8. Organization of the ferritin genes in Drosophila melanogaster. Dunkov, B.C., Georgieva, T. DNA Cell Biol. (1999) [Pubmed]
  9. Aedes aegypti ferritin heavy chain homologue: feeding of iron or blood influences message levels, lengths and subunit abundance. Dunkov, B.C., Georgieva, T., Yoshiga, T., Hall, M., Law, J.H. J. Insect Sci. (2002) [Pubmed]
  10. Secreted ferritin subunits are of two kinds in insects molecular cloning of cDNAs encoding two major subunits of secreted ferritin from Calpodes ethlius. Nichol, H., Locke, M. Insect Biochem. Mol. Biol. (1999) [Pubmed]
  11. Drosophila melanogaster ferritin: cDNA encoding a light chain homologue, temporal and tissue specific expression of both subunit types. Georgieva, T., Dunkov, B.C., Dimov, S., Ralchev, K., Law, J.H. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  12. Cloning and expression of a ferritin subunit for Galleria mellonella. Kim, B.S., Yun, C.Y., Yeo, S.M., Lee, H.J., Kim, H.R. Arch. Insect Biochem. Physiol. (2001) [Pubmed]
  13. Cloning and molecular characterization of two mosquito iron regulatory proteins. Zhang, D., Dimopoulos, G., Wolf, A., Miñana, B., Kafatos, F.C., Winzerling, J.J. Insect Biochem. Mol. Biol. (2002) [Pubmed]
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