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Gene Review

FMO3  -  flavin containing monooxygenase 3

Pan troglodytes

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High impact information on FMO3

  • The evolutionary history of the FMO3 gene was inferred from the pattern of haplotype relationships across different populations and species [1].
  • Exon sequence analysis of the monkey FMO3 gene sequence showed that it was similar to the human gene sequence but differed from the human consensus sequence at 31 fixed positions [1].
  • We also compared the genetic variation of nonhuman primate FMO3 with the human FMO3 gene [1].
  • For example, abnormal N-oxygenation of trimethylamine has been shown to segregate with mutations of human FMO3 [1].
  • Statistically significant heterogeneity in the relative frequencies of single and multiple site alleles, haplotypes, and genotypes of the human FMO3 among ethnic subdivisions suggests that population differences in the susceptibility of humans to abnormal metabolism or adverse drug reactions for chemicals metabolized by human FMO3 could exist [1].


  1. Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms. Cashman, J.R., Zhang, J., Leushner, J., Braun, A. Drug Metab. Dispos. (2001) [Pubmed]
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