Gene Review:
FMO3 - flavin containing monooxygenase 3
Homo sapiens
Synonyms:
Dimethylaniline oxidase 3, FMO 3, FMO II, FMO form 2, FMOII, ...
Ohmi,
Yoshida,
Endo,
Hasegawa,
Akimoto,
Higuchi,
Furnes,
Schlenk,
Hines,
Hopp,
Franco,
Saeian,
Begun,
Parte,
Kupfer,
Smith,
Crespi,
Cashman,
Bi,
Lin,
Youil,
Knight,
Forrest,
Treacy,
Woenckhaus,
Klein-Hitpass,
Grepmeier,
Merk,
Pfeifer,
Wild,
Bettstetter,
Wuensch,
Blaszyk,
Hartmann,
Hofstaedter,
Dietmaier,
- Regio- and stereoselective oxygenations by adult human liver flavin-containing monooxygenase 3. Comparison with forms 1 and 2. Lomri, N., Yang, Z., Cashman, J.R. Chem. Res. Toxicol. (1993)
- Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3. Qian, L., Ortiz de Montellano, P.R. Chem. Res. Toxicol. (2006)
- Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers. Woenckhaus, M., Klein-Hitpass, L., Grepmeier, U., Merk, J., Pfeifer, M., Wild, P., Bettstetter, M., Wuensch, P., Blaszyk, H., Hartmann, A., Hofstaedter, F., Dietmaier, W. J. Pathol. (2006)
- Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis. Hisamuddin, I.M., Wehbi, M.A., Schmotzer, B., Easley, K.A., Hylind, L.M., Giardiello, F.M., Yang, V.W. Cancer Epidemiol. Biomarkers Prev. (2005)
- Baculovirus-mediated expression and purification of human FMO3: catalytic, immunochemical, and structural characterization. Haining, R.L., Hunter, A.P., Sadeque, A.J., Philpot, R.M., Rettie, A.E. Drug Metab. Dispos. (1997)
- Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Dolphin, C.T., Janmohamed, A., Smith, R.L., Shephard, E.A., Phillips, I.R. Nat. Genet. (1997)
- Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver. Lomri, N., Gu, Q., Cashman, J.R. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication. Treacy, E.P., Akerman, B.R., Chow, L.M., Youil, R., Bibeau, C., Lin, J., Bruce, A.G., Knight, M., Danks, D.M., Cashman, J.R., Forrest, S.M. Hum. Mol. Genet. (1998)
- Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. Koukouritaki, S.B., Poch, M.T., Cabacungan, E.T., McCarver, D.G., Hines, R.N. Mol. Pharmacol. (2005)
- Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria. Zhang, J., Tran, Q., Lattard, V., Cashman, J.R. Pharmacogenetics (2003)
- Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria. Cashman, J.R., Bi, Y.A., Lin, J., Youil, R., Knight, M., Forrest, S., Treacy, E. Chem. Res. Toxicol. (1997)
- Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. Cashman, J.R., Park, S.B., Berkman, C.E., Cashman, L.E. Chem. Biol. Interact. (1995)
- Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3. Smith, P.B., Crespi, C. Biochem. Pharmacol. (2002)
- Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase. Hines, R.N., Hopp, K.A., Franco, J., Saeian, K., Begun, F.P. Mol. Pharmacol. (2002)
- Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA. Dolphin, C.T., Riley, J.H., Smith, R.L., Shephard, E.A., Phillips, I.R. Genomics (1997)
- Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. McCombie, R.R., Dolphin, C.T., Povey, S., Phillips, I.R., Shephard, E.A. Genomics (1996)
- Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q. Shephard, E.A., Dolphin, C.T., Fox, M.F., Povey, S., Smith, R., Phillips, I.R. Genomics (1993)
- Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. Dalmadi, B., Leibinger, J., Szeberényi, S., Borbás, T., Farkas, S., Szombathelyi, Z., Tihanyi, K. Drug Metab. Dispos. (2003)
- The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture. Pichard-Garcia, L., Weaver, R.J., Eckett, N., Scarfe, G., Fabre, J.M., Lucas, C., Maurel, P. Drug Metab. Dispos. (2004)
- Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3. Matal, J., Orsag, J., Nekvindova, J., Anzenbacherova, E., Veinlichova, A., Anzenbacher, P., Zidek, Z., Holy, A. Neuro Endocrinol. Lett. (2006)
- Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases. Comparison of human liver and kidney microsomes and mammalian enzymes. Hamman, M.A., Haehner-Daniels, B.D., Wrighton, S.A., Rettie, A.E., Hall, S.D. Biochem. Pharmacol. (2000)
- In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. Lang, D.H., Rettie, A.E. British journal of clinical pharmacology. (2000)
- Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes. Furnes, B., Schlenk, D. Toxicol. Sci. (2004)
- Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. Parte, P., Kupfer, D. Drug Metab. Dispos. (2005)
- 6-methylhydroxylation of the anti-cancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by flavin-containing monooxygenase 3. Zhou, S., Kestell, P., Paxton, J.W. European journal of drug metabolism and pharmacokinetics. (2002)
- Detoxication of tyramine by the flavin-containing monooxygenase: stereoselective formation of the trans oxime. Lin, J., Cashman, J.R. Chem. Res. Toxicol. (1997)
- Alternative processing events in human FMO genes. Lattard, V., Zhang, J., Cashman, J.R. Mol. Pharmacol. (2004)
- S-oxidation of S-methyl-esonarimod by flavin-containing monooxygenases in human liver microsomes. Ohmi, N., Yoshida, H., Endo, H., Hasegawa, M., Akimoto, M., Higuchi, S. Xenobiotica (2003)
- Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Störmer, E., Brockmöller, J., Roots, I., Schmider, J. Psychopharmacology (Berl.) (2000)
- Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes. Rawden, H.C., Kokwaro, G.O., Ward, S.A., Edwards, G. British journal of clinical pharmacology. (2000)
- Investigation of structure and function of a catalytically efficient variant of the human flavin-containing monooxygenase form 3. Borb??s, T., Zhang, J., Cerny, M.A., Lik??, I., Cashman, J.R. Drug Metab. Dispos. (2006)
- Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes. Ripp, S.L., Itagaki, K., Philpot, R.M., Elfarra, A.A. Drug Metab. Dispos. (1999)
- A novel mutation in the flavin-containing monooxygenase 3 gene, FM03, that causes fish-odour syndrome: activity of the mutant enzyme assessed by proton NMR spectroscopy. Murphy, H.C., Dolphin, C.T., Janmohamed, A., Holmes, H.C., Michelakakis, H., Shephard, E.A., Chalmers, R.A., Phillips, I.R., Iles, R.A. Pharmacogenetics (2000)