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Gene Review:

Fmo3 - flavin containing monooxygenase 3

Mus musculus

Synonyms: AW111792, Dimethylaniline oxidase 3, FMO 3, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase

Falls, J.G. et al., Falls, J.G. et al., Tijet, N. et al., Falls, J.G. et al.

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Disease relevance of Fmo3

Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): comparison with the human isoform [1].

High impact information on Fmo3

The flavin-containing monooxygenases, Fmo2 and Fmo3, considered previously to be uninducible, were highly induced by TCDD in an AHR-dependent manner [2].
In addition, testosterone administration to females (sexually intact and gonadectomized animals) reduced FMO1 expression and obviated FMO3 expression [3].
In males, castration dramatically increased FMO3 and FMO1 expression, and testosterone replacement to castrated males resulted in ablation of FMO3 expression [3].

Associations of Fmo3 with chemical compounds

Interestingly, FMO1 protein levels were increased in sexually intact males following treatment with 17 beta-estradiol; however, only a slight increase in FMO3 protein level was observed [3].

Other interactions of Fmo3

Protein and mRNA levels appear to be coregulated with regard to gender-selective or gender-specific expression of FMO1 or FMO3, respectively [4].

References

Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): comparison with the human isoform. Falls, J.G., Cherrington, N.J., Clements, K.M., Philpot, R.M., Levi, P.E., Rose, R.L., Hodgson, E. Arch. Biochem. Biophys. (1997) [Pubmed]
Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries. Tijet, N., Boutros, P.C., Moffat, I.D., Okey, A.B., Tuomisto, J., Pohjanvirta, R. Mol. Pharmacol. (2006) [Pubmed]
Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids. Falls, J.G., Ryu, D.Y., Cao, Y., Levi, P.E., Hodgson, E. Arch. Biochem. Biophys. (1997) [Pubmed]
Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice. Falls, J.G., Blake, B.L., Cao, Y., Levi, P.E., Hodgson, E. J. Biochem. Toxicol. (1995) [Pubmed]

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