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Fmo3  -  flavin containing monooxygenase 3

Rattus norvegicus

Synonyms: Dimethylaniline oxidase 3, FMO 3, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase
 
 
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Disease relevance of Fmo3

 

High impact information on Fmo3

  • FMO3 and FMO5 increased in liver microsomes with age [2].
  • Inversely, the expression of FMO1 in the female rat kidneys does not seem to be modified as a function of age while the expression of FMO3 is strongly increased [3].
  • The data suggest that total parenteral nutrition has a detectable effect on modulating rat FMO3, FMO4, and CYP2E1 monooxygenase functional activity [4].
  • The metabolism of benzydamine to its major metabolite, the N-oxide, is mediated by FMO3 in humans [5].
  • Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3 [1].
 

Anatomical context of Fmo3

  • Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: immunochemical and kinetic evidence for FMO3 being the major catalyst [6].
 

Associations of Fmo3 with chemical compounds

  • The findings that the methionine S-oxidase reacted intensely with antibodies raised against rabbit FMO3 and the SBC S-oxidase reacted intensely with antibodies raised against rabbit FMO1 provide evidence for these activities being associated with FMO3 and FMO1, respectively [6].
  • Recombinant rat FMO3 showed activities of methimazole S-oxidation, and NADPH oxidation associated with the N- or S-oxidation of trimethylamine and thioacetamide, in good concordance with those reported for human FMO3 [1].
 

Analytical, diagnostic and therapeutic context of Fmo3

  • The sequence of rat FMO3 was obtained by RT-PCR and 5'/3' terminal extension [1].

References

  1. Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3. Lattard, V., Buronfosse, T., Lachuer, J., Longin-Sauvageon, C., Moulin, C., Benoit, E. Arch. Biochem. Biophys. (2001) [Pubmed]
  2. Age-related susceptibility to 3,3'-iminodipropionitrile-induced olfactory mucosal damage. Genter, M.B., Ali, S.F. Neurobiol. Aging (1998) [Pubmed]
  3. Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney. Lattard, V., Lachuer, J., Buronfosse, T., Garnier, F., Benoit, E. Biochem. Pharmacol. (2002) [Pubmed]
  4. Effect of total parenteral nutrition and choline on hepatic flavin-containing and cytochrome P-450 monooxygenase activity in rats. Cashman, J.R., Lattard, V., Lin, J. Drug Metab. Dispos. (2004) [Pubmed]
  5. Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance. Fisher, M.B., Yoon, K., Vaughn, M.L., Strelevitz, T.J., Foti, R.S. Drug Metab. Dispos. (2002) [Pubmed]
  6. Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: immunochemical and kinetic evidence for FMO3 being the major catalyst. Krause, R.J., Ripp, S.L., Sausen, P.J., Overby, L.H., Philpot, R.M., Elfarra, A.A. Arch. Biochem. Biophys. (1996) [Pubmed]
 
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