Gene Review:
MYO1D - myosin ID
Homo sapiens
Synonyms:
KIAA0727, PPP1R108, Unconventional myosin-Id, myr4
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Disease relevance of MYO1D
- Mutations in Myosin ID completely reverse the left-right axis (situs inversus), a phenotype that is dependent on an intact actin cytoskeleton [1].
High impact information on MYO1D
- How this myosin might orient the left-right axis has began to be elucidated by showing that it interacts directly with beta-catenin, suggesting that myosin ID interacts with the adherens junction to control the direction of organ looping [1].
References
- Left-right asymmetry: class I myosins show the direction. Spéder, P., Noselli, S. Curr. Opin. Cell Biol. (2007) [Pubmed]
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