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Gene Review

Myo31DF  -  Myosin 31DF

Drosophila melanogaster

Synonyms: BBMIA, Brush border myosin IA, CG7438, Dm IA, DmIA, ...
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Disease relevance of Myo31DF


Psychiatry related information on Myo31DF


High impact information on Myo31DF

  • In the adult gut, MIA and MIB both exhibit a microvillar component as MIA attains a more apical position in addition to its previous terminal web locale [2].
  • Characterization of myosin-IA and myosin-IB, two unconventional myosins associated with the Drosophila brush border cytoskeleton [2].
  • MIA and MIB, both found predominantly at the basolateral domain of immature enterocytes, exhibit increased expression at the apical domain of differentiated enterocytes co-incident with microvillus assembly [2].
  • Characterization of clones from a Drosophila Class IA- cDNA library reveals that 18S rRNA and transcripts derived from intermediate repeat DNA constitute the bulk of such molecules [3].
  • Disruption of actin filaments in the hindgut epithelium randomizes the handedness of the embryonic gut, suggesting that Myo31DF function requires the actin cytoskeleton [4].

Anatomical context of Myo31DF


Other interactions of Myo31DF

  • Although both are myosins-I from fly, myosin-IA at cytological locus 31D-F and myosin-IB at cytological locus 61F appear to be more similar to their vertebrate homologs than they are to each other [5].

Analytical, diagnostic and therapeutic context of Myo31DF


  1. Type ID unconventional myosin controls left-right asymmetry in Drosophila. Spéder, P., Adám, G., Noselli, S. Nature (2006) [Pubmed]
  2. Characterization of myosin-IA and myosin-IB, two unconventional myosins associated with the Drosophila brush border cytoskeleton. Morgan, N.S., Heintzelman, M.B., Mooseker, M.S. Dev. Biol. (1995) [Pubmed]
  3. Interstrand duplexes in hnRNA: the occurrence of retrotransposon antisense sequences. Miller, K., Rosenbaum, J., Zbrzezna, V., Pogo, A. Cell. Mol. Biol. (1990) [Pubmed]
  4. An unconventional myosin in Drosophila reverses the default handedness in visceral organs. Hozumi, S., Maeda, R., Taniguchi, K., Kanai, M., Shirakabe, S., Sasamura, T., Spéder, P., Noselli, S., Aigaki, T., Murakami, R., Matsuno, K. Nature (2006) [Pubmed]
  5. The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. Morgan, N.S., Skovronsky, D.M., Artavanis-Tsakonas, S., Mooseker, M.S. J. Mol. Biol. (1994) [Pubmed]
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