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Gene Review

Myo1d  -  myosin ID

Rattus norvegicus

Synonyms: Myo1c, Myosin heavy chain myr 4, Myr2, Myr4, Unconventional myosin-Id
 
 
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Disease relevance of Myo1d

  • Myo1c was found in hair-cell stereocilia, concentrated towards their tips; we confirmed this localization by using adenovirus vectors to direct expression of a GFP-Myo1c tail fusion protein; this fusion protein localized to plasma membranes, often concentrating at stereociliary tips [1].
 

High impact information on Myo1d

 

Anatomical context of Myo1d

References

  1. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont, R.A., Zhao, Y.D., Holt, J.R., Bähler, M., Gillespie, P.G. J. Assoc. Res. Otolaryngol. (2002) [Pubmed]
  2. Myo1c is designed for the adaptation response in the inner ear. Batters, C., Arthur, C.P., Lin, A., Porter, J., Geeves, M.A., Milligan, R.A., Molloy, J.E., Coluccio, L.M. EMBO J. (2004) [Pubmed]
  3. Rat myr 4 defines a novel subclass of myosin I: identification, distribution, localization, and mapping of calmodulin-binding sites with differential calcium sensitivity. Bähler, M., Kroschewski, R., Stöffler, H.E., Behrmann, T. J. Cell Biol. (1994) [Pubmed]
  4. Activation of myosin-I by members of the Ste20p protein kinase family. Wu, C., Lee, S.F., Furmaniak-Kazmierczak, E., Côté, G.P., Thomas, D.Y., Leberer, E. J. Biol. Chem. (1996) [Pubmed]
  5. Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains. Ruppert, C., Godel, J., Müller, R.T., Kroschewski, R., Reinhard, J., Bähler, M. J. Cell. Sci. (1995) [Pubmed]
  6. A model of stereocilia adaptation based on single molecule mechanical studies of myosin I. Batters, C., Wallace, M.I., Coluccio, L.M., Molloy, J.E. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2004) [Pubmed]
  7. Axonal isoforms of myosin-I. Lund, L.M., Machado, V.M., McQuarrie, I.G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
 
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