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Gene Review

NAP1L3  -  nucleosome assembly protein 1-like 3

Homo sapiens

Synonyms: BNAP, MB20, MGC26312, NPL3, Nucleosome assembly protein 1-like 3
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Disease relevance of NAP1L3


High impact information on NAP1L3

  • When the triglyceride contents of Tangier LDL were reduced to 10% of mass by incubation with normal high density lipoproteins, production of the 120-kDa fragment by proteolysis decreased and MB20 binding increased in affinity, implying a change toward normal conformation of apoB-100 [2].
  • On the basis of its expression pattern, predicted sequence, and protein properties, we propose that MB20 plays a unique role in modulating nucleosome structure and gene expression during brain development [3].
  • Transient transfection and immunofluorescence microscopy demonstrated that MB20 is distributed in the cytoplasm as well as in the nucleus [3].
  • A new member of the NAP/SET gene family, named MB20, was isolated from a mouse brain cDNA library by virtue of its CAG trinucleotide repetitive sequence and a brain-specific gene expression pattern [3].
  • The ability of MB20 to bind histone proteins was analyzed by sucrose gradient sedimentation and by retention of histone proteins by immobilized MB20 protein [3].

Analytical, diagnostic and therapeutic context of NAP1L3

  • In competitive radioimmunoassay, Tangier LDL bound weakly to the apoB-specific monoclonal antibody MB20, compared with control LDL [2].


  1. Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide homologous to human and yeast nucleosome assembly proteins. Watanabe, T.K., Fujiwara, T., Nakamura, Y., Hirai, Y., Maekawa, H., Takahashi, E. Cytogenet. Cell Genet. (1996) [Pubmed]
  2. Conformation of apolipoprotein B-100 in the low density lipoproteins of tangier disease. Identification of localized conformational response to triglyceride content. Kunitake, S.T., Young, S.G., Chen, G.C., Pullinger, C.R., Zhu, S., Pease, R.J., Scott, J., Hass, P., Schilling, J., Kane, J.P. J. Biol. Chem. (1990) [Pubmed]
  3. Identification and characterization of a SET/NAP protein encoded by a brain-specific gene, MB20. Shen, H.H., Huang, A.M., Hoheisel, J., Tsai, S.F. Genomics (2001) [Pubmed]
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