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Gene Review: 

mus205  -  mutagen-sensitive 205

Drosophila melanogaster

Synonyms: 154926_at, AAF59191, CG1925, DhRev3, DmREV3, ...
 
 
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High impact information on mus205

  • Rrp1 directly interacted with DmREV7 in vitro and in vivo but not with DmREV3 [1].
  • This phenotype of the Drosophila mus205 mutant is strikingly different from the phenotype of the yeast rev3 mutant, which is hypomutable after UV, X-rays, NQO and alkylating agents [2].
  • 2 mutants, classified as completely or partially proficient for both excision and postreplication repair of UV damage, mus(1)103 and mus(2)205, were found to give positive UDS responses only for UV damage [3].
  • Mutants at five different genetic loci [mus(2)205, mus(3)304, mus(3)308, mus(3)310 and mus(3)311] possess a reduced capacity to synthesize DNA on a UV-damaged template in primary cell cultures [4].
 

Associations of mus205 with chemical compounds

References

  1. Drosophila DNA Polymerase {zeta} Interacts with Recombination Repair Protein 1, the Drosophila Homologue of Human Abasic Endonuclease 1. Takeuchi, R., Ruike, T., Nakamura, R., Shimanouchi, K., Kanai, Y., Abe, Y., Ihara, A., Sakaguchi, K. J. Biol. Chem. (2006) [Pubmed]
  2. Isolation and genetic characterisation of the Drosophila homologue of (SCE)REV3, encoding the catalytic subunit of DNA polymerase zeta. Eeken, J.C., Romeijn, R.J., de Jong, A.W., Pastink, A., Lohman, P.H. Mutat. Res. (2001) [Pubmed]
  3. Mutations at the mei-41, mus(1)101, mus(1)103, mus(2)205 and mus(3)310 loci of Drosophila exhibit differential UDS responses with different DNA-damaging agents. Dusenbery, R.L. Mutat. Res. (1987) [Pubmed]
  4. Postreplication repair defects in mutants of Drosophila melanogaster. Boyd, J.B., Shaw, K.E. Mol. Gen. Genet. (1982) [Pubmed]
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