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Gene Review

mei-41  -  meiotic 41

Drosophila melanogaster

Synonyms: 4252, ATR, ATR homolog, Ataxia telangiectasia and Rad3-related protein homolog, CG4252, ...
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Disease relevance of mei-41


High impact information on mei-41


Chemical compound and disease context of mei-41


Biological context of mei-41

  • Of these, mutants deficient in DNA repair, mei-41 and okra, show progressive degeneration of imaginal discs and die as pupae, while other genotypes survive to adulthood after irradiation [8].
  • mei-41 and bub1 block mitosis at two distinct steps in response to incomplete DNA replication in Drosophila embryos [9].
  • BACKGROUND: During Drosophila oogenesis, unrepaired double-strand DNA breaks activate a mei-41-dependent meiotic checkpoint, which couples the progression through meiosis to specific developmental processes [10].
  • These developmental phenotypes are unique to dATM, and both dATM and mei-41 have temporally distinct roles in G2 arrest after IR [11].
  • We also tested the role of mei-41 in a recently characterized checkpoint that delays metaphase/anaphase transition after DNA damage in cellular embryos [1].

Anatomical context of mei-41

  • X-Irradiation of spermatids significantly increased the preferential elimination of the P-element-bearing second chromosome in mei-41, DNA-repair-deficient dysgenic males, but had no effect in their DNA-repair-proficient brothers [12].

Associations of mei-41 with chemical compounds


Regulatory relationships of mei-41


Other interactions of mei-41


Analytical, diagnostic and therapeutic context of mei-41

  • Molecular cloning of mei-41, a gene that influences both somatic and germline chromosome metabolism of Drosophila melanogaster [4].
  • The frequencies of sex-linked recessive lethal mutations in flight groups were 2 and 3 times higher for wild type Canton-S and mei-41 strains, respectively, than those in ground control groups [21].
  • Sequence analysis identified mutations, which, for most alleles, fall in the poorly characterized region outside the kinase domain; this allowed us to tentatively identify additional functional domains of MEI-41 that could be subjected to future structure-function studies of this key molecule [1].
  • ATM/ATR kinases act as signal transducers in eukaryotic DNA damage and replication checkpoints [1].


  1. Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Laurençon, A., Purdy, A., Sekelsky, J., Hawley, R.S., Su, T.T. Genetics (2003) [Pubmed]
  2. Drosophila ATR in Double-Strand Break Repair. Larocque, J.R., Jaklevic, B., Su, T.T., Sekelsky, J. Genetics (2007) [Pubmed]
  3. Hypersensitivity of Drosophila mei-41 mutants to hydroxyurea is associated with reduced mitotic chromosome stability. Banga, S.S., Shenkar, R., Boyd, J.B. Mutat. Res. (1986) [Pubmed]
  4. Molecular cloning of mei-41, a gene that influences both somatic and germline chromosome metabolism of Drosophila melanogaster. Banga, S.S., Yamamoto, A.H., Mason, J.M., Boyd, J.B. Mol. Gen. Genet. (1995) [Pubmed]
  5. A high level of hybrid dysgenesis in Drosophila: high thermosensitivity, dependence on DNA repair, and incomplete cytotype regulation. Margulies, L. Mol. Gen. Genet. (1990) [Pubmed]
  6. The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Hari, K.L., Santerre, A., Sekelsky, J.J., McKim, K.S., Boyd, J.B., Hawley, R.S. Cell (1995) [Pubmed]
  7. mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development. Brodsky, M.H., Sekelsky, J.J., Tsang, G., Hawley, R.S., Rubin, G.M. Genes Dev. (2000) [Pubmed]
  8. Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae. Jaklevic, B.R., Su, T.T. Curr. Biol. (2004) [Pubmed]
  9. mei-41 and bub1 block mitosis at two distinct steps in response to incomplete DNA replication in Drosophila embryos. Garner, M., van Kreeveld, S., Su, T.T. Curr. Biol. (2001) [Pubmed]
  10. Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk. Abdu, U., Brodsky, M., Schüpbach, T. Curr. Biol. (2002) [Pubmed]
  11. The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Song, Y.H., Mirey, G., Betson, M., Haber, D.A., Settleman, J. Curr. Biol. (2004) [Pubmed]
  12. Radiation and transposon-induced genetic damage in Drosophila melanogaster: X-ray dose-response and synergism with DNA-repair deficiency. Balter, H., Griffith, C.S., Margulies, L. Mutat. Res. (1992) [Pubmed]
  13. Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable. de Vries, H.I., Uyetake, L., Lemstra, W., Brunsting, J.F., Su, T.T., Kampinga, H.H., Sibon, O.C. J. Cell. Sci. (2005) [Pubmed]
  14. Identification of cellular factors that recognize UV-damaged DNA in Drosophila melanogaster. Todo, T., Ryo, H. Mutat. Res. (1992) [Pubmed]
  15. CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint. Doronkin, S., Djagaeva, I., Beckendorf, S.K. Development (2002) [Pubmed]
  16. Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage. Nakayama, M., Maruyama, S., Kanda, H., Ohkita, N., Nakano, K., Ito, F., Kawasaki, K. FEBS Lett. (2006) [Pubmed]
  17. The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Ciapponi, L., Cenci, G., Gatti, M. Genetics (2006) [Pubmed]
  18. Studies on mutagen-sensitive strains of Drosophila melanogaster. VI. The effect of DNA-repair deficiencies in spermatids, spermatocytes and spermatogonia irradiated in N2 or O2. Eeken, J.C., Sobels, F.H. Mutat. Res. (1985) [Pubmed]
  19. Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis. Price, D., Rabinovitch, S., O'Farrell, P.H., Campbell, S.D. Genetics (2000) [Pubmed]
  20. ATM and ATR Pathways Signal Alternative Splicing of Drosophila TAF1 Pre-mRNA in Response to DNA Damage. Katzenberger, R.J., Marengo, M.S., Wassarman, D.A. Mol. Cell. Biol. (2006) [Pubmed]
  21. Mutations induced in Drosophila during space flight. Ikenaga, M., Yoshikawa, I., Kojo, M., Ayaki, T., Ryo, H., Ishizaki, K., Kato, T., Yamamoto, H., Hara, R. Biol. Sci. Space (1997) [Pubmed]
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