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Gene Review

c(3)G  -  crossover suppressor on 3 of Gowen

Drosophila melanogaster

Synonyms: C(3)G, C3G, CG17604, Dmel\CG17604, c(3)g, ...
 
 
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High impact information on c(3)G

  • c(3)G encodes a Drosophila synaptonemal complex protein [1].
  • Immunolocalization of the C(3)G protein, as well as the analysis of a C(3)G-eGFP expression construct, reveals that C(3)G is present in a thread-like pattern along the lengths of chromosomes in meiotic prophase, consistent with a role as an SC protein present on meiotic bivalents [1].
  • Based on our data and the known phenotypes of C(2)M and C(3)G mutants, we propose a model of SC structure in which C(2)M links C(3)G to the LEs [2].
  • Despite having a defect in C(3)G localization, c(2)M mutants unexpectedly affect crossing over less severely than a c(3)G mutant [3].
  • In wild-type oocytes, homologs are paired along their entire lengths prior to accumulation of the SC protein C(3)G [4].
 

Biological context of c(3)G

  • By using an antibody to C(3)G as a marker for synaptonemal complex (SC) formation, we observed that SC is present before MEI-P22 associates with the chromosomes, thus providing direct evidence that the development of SC precedes the initiation of meiotic recombination [5].
 

Anatomical context of c(3)G

  • In the absence of two SC proteins, C(3)G and C(2)M, the number of DSBs in oocytes is significantly reduced [6].
 

Other interactions of c(3)G

  • Similarly, we found that MEI-P22 foci did not appear in a c(3)G mutant in which SC does not form, suggesting that DSB formation is dependent on SC formation in Drosophila [5].
  • The appearance of C(3)G-independent crossovers in c(2)M mutants suggests that C(2)M prevents recombination in the absence of complete SC formation [3].

References

  1. c(3)G encodes a Drosophila synaptonemal complex protein. Page, S.L., Hawley, R.S. Genes Dev. (2001) [Pubmed]
  2. Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complex. Anderson, L.K., Royer, S.M., Page, S.L., McKim, K.S., Lai, A., Lilly, M.A., Hawley, R.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. The Synaptonemal complex component C(2)M regulates meiotic crossing over in Drosophila. Manheim, E.A., McKim, K.S. Curr. Biol. (2003) [Pubmed]
  4. Meiotic recombination in Drosophila females depends on chromosome continuity between genetically defined boundaries. Sherizen, D., Jang, J.K., Bhagat, R., Kato, N., McKim, K.S. Genetics (2005) [Pubmed]
  5. mei-P22 encodes a chromosome-associated protein required for the initiation of meiotic recombination in Drosophila melanogaster. Liu, H., Jang, J.K., Kato, N., McKim, K.S. Genetics (2002) [Pubmed]
  6. Temporal analysis of meiotic DNA double-strand break formation and repair in Drosophila females. Mehrotra, S., McKim, K.S. PLoS Genet. (2006) [Pubmed]
 
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