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Gene Review

cdc6  -  cell division cycle 6

Xenopus (Silurana) tropicalis

 
 
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High impact information on cdc6

 

Biological context of cdc6

  • Before initiation of DNA replication, origin recognition complex (ORC) proteins, cdc6, and minichromosome maintenance (MCM) proteins bind to chromatin sequentially and form preinitiation complexes [3].

References

  1. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Coleman, T.R., Carpenter, P.B., Dunphy, W.G. Cell (1996) [Pubmed]
  2. Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation. Lemaître, J.M., Bocquet, S., Méchali, M. Nature (2002) [Pubmed]
  3. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2. Hua, X.H., Newport, J. J. Cell Biol. (1998) [Pubmed]
  4. Developmental regulation of MCM replication factors in Xenopus laevis. Sible, J.C., Erikson, E., Hendrickson, M., Maller, J.L., Gautier, J. Curr. Biol. (1998) [Pubmed]
  5. Identification and characterization of a mouse homolog to yeast Cdc6p. Berger, C., Strub, A., Staib, C., Lepke, M., Zisimopoulou, P., Hoehn, K., Nanda, I., Schmid, M., Grummt, F. Cytogenet. Cell Genet. (1999) [Pubmed]
 
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