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Gene Review:

ANPEP - alanyl (membrane) aminopeptidase

Felis catus

Tresnan, D.B. et al., Rossen, J.W. et al., Miguel, B. et al.

Tresnan, Levis, Holmes,

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Disease relevance of ANPEP

In contrast, fAPN did not serve as a functional receptor for mouse hepatitis virus (MHV-A59), which is in serogroup II and utilizes mouse biliary glycoprotein receptors unrelated to APN [1].
Two members of coronavirus serogroup I, human respiratory coronavirus HCV-229E and porcine transmissible gastroenteritis virus (TGEV), use aminopeptidase N (APN) as their cellular receptors [1].
In this study feline (FECV and FIPV) and canine (CCoV) coronavirus entry into and release from polarized porcine epithelial LLC-PK1 cells, stably expressing the recombinant feline aminopeptidase-N cDNA, were investigated [2].
The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review [3].
Feline and canine coronaviruses are released from the basolateral side of polarized epithelial LLC-PK1 cells expressing the recombinant feline aminopeptidase-N cDNA [2].

High impact information on ANPEP

The predicted amino acid sequence of fAPN shows 78 and 77% identity with human and porcine APN, respectively [1].
These viruses show marked species specificity in receptor utilization, as HCV-229E can utilize human but not porcine APN, while TGEV can utilize porcine but not human APN [1].

References

Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I. Tresnan, D.B., Levis, R., Holmes, K.V. J. Virol. (1996) [Pubmed]
Feline and canine coronaviruses are released from the basolateral side of polarized epithelial LLC-PK1 cells expressing the recombinant feline aminopeptidase-N cDNA. Rossen, J.W., Kouame, J., Goedheer, A.J., Vennema, H., Rottier, P.J. Arch. Virol. (2001) [Pubmed]
The role of feline aminopeptidase N as a receptor for infectious bronchitis virus. Brief review. Miguel, B., Pharr, G.T., Wang, C. Arch. Virol. (2002) [Pubmed]

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