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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Species Specificity

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Disease relevance of Species Specificity


High impact information on Species Specificity

  • The receptor has high affinity (KD, 174 pM) for human IFN alpha and, unlike other type I IFN receptors, has broad species specificity, binding to human, rabbit, bovine, rat, and mouse type I IFNs [6].
  • This species specificity might reflect differences in DNA-binding properties and/or interactions with activator proteins or other components of the RNA polymerase II transcription machinery [7].
  • But there is little or no species specificity in cytotoxicity of murine TNF and human TNF on human as well as on murine cell lines [8].
  • The antigen defined by 12E7 is not expressed on mouse or hamster cells; this species specificity allowed us to investigate the genetics of the expression of the 12E7 antigen using human--rodent somatic-cell hybrids [9].
  • It was shown that sp56 expression is restricted to mouse spermatids and that the presence or absence of sp56 on sperm from different species accounts for species specificity of sperm-egg recognition in mice [10].

Chemical compound and disease context of Species Specificity


Biological context of Species Specificity

  • Because of the species-specificity of tissue factor activity and the availability of a very sensitive chromogenic assay, it was possible in the present study to use somatic cell hybrids to assign the chromosomal location of the tissue factor structural gene (F3) to human chromosome 1 (1pter----1p21) [16].
  • These results demonstrate species specificity of splicing signals, particularly pyrimidine stretch and size requirements, and raise the possibility that variant mechanisms not found in mammals may operate in the splicing of small introns in Drosophila and possibly other species [17].
  • Histology of the tumors in both groups showed no marked infiltration of the tumors with murine hematopoietic and lymphocytic cells consistent with the species specificity of IL-4 [18].
  • We conducted a genomic analysis of an orthologous pair of mouse and rat V1R gene clusters to test for species specificity in rodent pheromone systems [19].
  • Unlike many of the activities displayed by TNF-alpha, its ability to induce CT6 cell proliferation shows strict species specificity as indicated by the failure of human rTNF-alpha to stimulate these cells [20].

Anatomical context of Species Specificity


Associations of Species Specificity with chemical compounds

  • The most variable region, which may account for lysin's species specificity, is at the NH2 terminus, where 11 of the 15 amino acids differ between the two species [26].
  • A single arginine residue determines species specificity of the human growth hormone receptor [27].
  • However, amino acid disparities were found in the epidermal growth factor-2/serine protease regions that are present in the human tissue factor-factor VIIa contact surface, suggesting a structural basis for the species specificity of this interaction [28].
  • The peptides showed complete species specificity and analogues of one peptide (speract) caused decreases in enzyme activity coincident with their receptor binding properties [29].
  • These results demonstrate that species specificity of fertilization in sea urchins depends in part on the fine structure of egg jelly sulfated polysaccharide [30].

Gene context of Species Specificity


Analytical, diagnostic and therapeutic context of Species Specificity


  1. Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation. Purdue, P.E., Allsop, J., Isaya, G., Rosenberg, L.E., Danpure, C.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Characterization of erythropoietin produced by IW32 murine erythroleukemia cells. Choppin, J., Lacombe, C., Casadevall, N., Muller, O., Tambourin, P., Varet, B. Blood (1984) [Pubmed]
  3. Species-specific functional interactions of DNA polymerase alpha-primase with simian virus 40 (SV40) T antigen require SV40 origin DNA. Schneider, C., Weisshart, K., Guarino, L.A., Dornreiter, I., Fanning, E. Mol. Cell. Biol. (1994) [Pubmed]
  4. Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors. Taketani, S., Immenschuh, S., Go, S., Sinclair, P.R., Stockert, R.J., Liem, H.H., Muller Eberhard, U. Hepatology (1998) [Pubmed]
  5. Anti-F(ab')2 antibodies that interfere with interpretation of the anti-C3 assay for immune complexes in children with rheumatic diseases. Olds, L.C., Miller, J.J. Arthritis Rheum. (1984) [Pubmed]
  6. Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity. Symons, J.A., Alcamí, A., Smith, G.L. Cell (1995) [Pubmed]
  7. Functional differences between yeast and human TFIID are localized to the highly conserved region. Cormack, B.P., Strubin, M., Ponticelli, A.S., Struhl, K. Cell (1991) [Pubmed]
  8. Human TNF mutants with selective activity on the p55 receptor. Van Ostade, X., Vandenabeele, P., Everaerdt, B., Loetscher, H., Gentz, R., Brockhaus, M., Lesslauer, W., Tavernier, J., Brouckaert, P., Fiers, W. Nature (1993) [Pubmed]
  9. A human quantitative polymorphism related to Xg blood groups. Goodfellow, P.N., Tippett, P. Nature (1981) [Pubmed]
  10. Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein. Bookbinder, L.H., Cheng, A., Bleil, J.D. Science (1995) [Pubmed]
  11. Regulation of Apobec3F and human immunodeficiency virus type 1 Vif by Vif-Cul5-ElonB/C E3 ubiquitin ligase. Liu, B., Sarkis, P.T., Luo, K., Yu, Y., Yu, X.F. J. Virol. (2005) [Pubmed]
  12. Biotin synthase of Bacillus subtilis shows less reactivity than that of Escherichia coli in in vitro reaction systems. Kiyasu, T., Asakura, A., Nagahashi, Y., Hoshino, T. Arch. Microbiol. (2002) [Pubmed]
  13. Renal effects of fumonisin mycotoxins in animals. Bucci, T.J., Howard, P.C., Tolleson, W.H., Laborde, J.B., Hansen, D.K. Toxicologic pathology. (1998) [Pubmed]
  14. Enteric infections with coronaviruses and toroviruses. Holmes, K.V. Novartis Found. Symp. (2001) [Pubmed]
  15. Immunology of celiac disease: tissue and species specificity of endomysial and reticulin antibodies. Valeski, J.E., Kumar, V., Beutner, E.H., Lerner, A., Chorzelski, T.P. Int. Arch. Allergy Appl. Immunol. (1990) [Pubmed]
  16. Tissue factor gene localized to human chromosome 1 (1pter----1p21). Carson, S.D., Henry, W.M., Shows, T.B. Science (1985) [Pubmed]
  17. Species-specific signals for the splicing of a short Drosophila intron in vitro. Guo, M., Lo, P.C., Mount, S.M. Mol. Cell. Biol. (1993) [Pubmed]
  18. Recombinant human interleukin-4 inhibits growth of some human lung tumor cell lines in vitro and in vivo. Topp, M.S., Koenigsmann, M., Mire-Sluis, A., Oberberg, D., Eitelbach, F., von Marschall, Z., Notter, M., Reufi, B., Stein, H., Thiel, E. Blood (1993) [Pubmed]
  19. Species specificity in rodent pheromone receptor repertoires. Lane, R.P., Young, J., Newman, T., Trask, B.J. Genome Res. (2004) [Pubmed]
  20. Tumor necrosis factor-alpha as a proliferative signal for an IL-2-dependent T cell line: strict species specificity of action. Ranges, G.E., Bombara, M.P., Aiyer, R.A., Rice, G.G., Palladino, M.A. J. Immunol. (1989) [Pubmed]
  21. Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma. Vandenabeele, P., Declercq, W., Vercammen, D., Van de Craen, M., Grooten, J., Loetscher, H., Brockhaus, M., Lesslauer, W., Fiers, W. J. Exp. Med. (1992) [Pubmed]
  22. Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity. Celada, A., Gray, P.W., Rinderknecht, E., Schreiber, R.D. J. Exp. Med. (1984) [Pubmed]
  23. Inhibition of mammalian DNA polymerases by recombinant alpha-interferon and gamma-interferon. Tanaka, M., Kimura, K., Yoshida, S. Cancer Res. (1987) [Pubmed]
  24. Brain isoenzyme of creatine kinase. II. Species specificity of enzyme and presence of inactive form in striated muscle of rabbit and man. Armstrong, J.B., Lowden, J.A., Sherwin, A.L. J. Biol. Chem. (1977) [Pubmed]
  25. Abrogation of species specificity for activation of tumoricidal properties in macrophages by recombinant mouse or human interferon-gamma encapsulated in liposomes. Fidler, I.J., Fogler, W.E., Kleinerman, E.S., Saiki, I. J. Immunol. (1985) [Pubmed]
  26. Species-specific sequences of abalone lysin, the sperm protein that creates a hole in the egg envelope. Vacquier, V.D., Carner, K.R., Stout, C.D. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  27. A single arginine residue determines species specificity of the human growth hormone receptor. Souza, S.C., Frick, G.P., Wang, X., Kopchick, J.J., Lobo, R.B., Goodman, H.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  28. Demonstration of the extrinsic coagulation pathway in teleostei: identification of zebrafish coagulation factor VII. Sheehan, J., Templer, M., Gregory, M., Hanumanthaiah, R., Troyer, D., Phan, T., Thankavel, B., Jagadeeswaran, P. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  29. Receptor-mediated regulation of guanylate cyclase activity in spermatozoa. Ramarao, C.S., Garbers, D.L. J. Biol. Chem. (1985) [Pubmed]
  30. Sulfated polysaccharides from the egg jelly layer are species-specific inducers of acrosomal reaction in sperms of sea urchins. Alves, A.P., Mulloy, B., Diniz, J.A., Mourão, P.A. J. Biol. Chem. (1997) [Pubmed]
  31. The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells. Gaspari, M., Falkenberg, M., Larsson, N.G., Gustafsson, C.M. EMBO J. (2004) [Pubmed]
  32. A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif). Schröfelbauer, B., Chen, D., Landau, N.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  33. The extracellular domain of the human interferon gamma receptor interacts with a species-specific signal transducer. Gibbs, V.C., Williams, S.R., Gray, P.W., Schreiber, R.D., Pennica, D., Rice, G., Goeddel, D.V. Mol. Cell. Biol. (1991) [Pubmed]
  34. Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin. Gurney, A.L., Kuang, W.J., Xie, M.H., Malloy, B.E., Eaton, D.L., de Sauvage, F.J. Blood (1995) [Pubmed]
  35. Expression and characterization of recombinant murine lactoferrin. Ward, P.P., Chu, H., Zhou, X., Conneely, O.M. Gene (1997) [Pubmed]
  36. Activity of human, bovine and porcine platelet-derived growth factor in a radioreceptor assay with human placental membrane protein. Czyrski, J.A., Gawlikowski, W. FEBS Lett. (1987) [Pubmed]
  37. A human T cell line established from a patient with Sézary syndrome. Application for assay of human interleukin 2 (IL-2). Namiuchi, S., Kumagai, S., Sano, H., Yodoi, J., Uchiyama, T., Ikai, K., Imura, H., Maeda, M. J. Immunol. Methods (1986) [Pubmed]
  38. ELISA for the measurement of serum and urinary chorionic gonadotropin concentrations in the laboratory macaque. Munro, C.J., Laughlin, L.S., Illera, J.C., Dieter, J., Hendrickx, A.G., Lasley, B.L. Am. J. Primatol. (1997) [Pubmed]
  39. Difference in species specificity of TSH receptor antibodies in Graves' disease and Hashimoto's thyroiditis. de Bruin, T.W. J. Endocrinol. Invest. (1988) [Pubmed]
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