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Gene Review:

AHNAK - AHNAK nucleoprotein

Canis lupus familiaris

Benaud, C. et al., Hashimoto, T. et al.

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High impact information on AHNAK

Down-regulation of both annexin 2 and S100A10 using an annexin 2-specific small interfering RNA inhibits the association of AHNAK with plasma membrane [1].
In Madin-Darby canine kidney cells, down-regulation of AHNAK using AHNAK-specific small interfering RNA prevents cortical actin cytoskeleton reorganization required to support cell height [1].
In Madin-Darby canine kidney cells, the protein AHNAK relocates from the cytosol to the cytosolic surface of the plasma membrane during the formation of cell-cell contacts and the development of epithelial polarity [1].
These results suggested an involvement of PKC in the translocation of the desmoyokin/AHNAK protein in keratinocytes [2].

References

AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. Benaud, C., Gentil, B.J., Assard, N., Court, M., Garin, J., Delphin, C., Baudier, J. J. Cell Biol. (2004) [Pubmed]
Regulation of translocation of the desmoyokin/AHNAK protein to the plasma membrane in keratinocytes by protein kinase C. Hashimoto, T., Gamou, S., Shimizu, N., Kitajima, Y., Nishikawa, T. Exp. Cell Res. (1995) [Pubmed]

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