The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

S100A10  -  S100 calcium binding protein A10

Homo sapiens

Synonyms: 42C, ANX2L, ANX2LG, CAL1L, CLP11, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of S100A10


Psychiatry related information on S100A10

  • Smith-Magenis syndrome (SMS) is a multiple congenital anomalies/mental retardation syndrome associated with an interstitial deletion of chromosome 17 involving band p11 [6].
  • The was a positive correlation between years of training undergone and the amplitude of N20, a negative correlation between the amplitudes of P11 and P13/14 and the number of hours of training undertaken per week, and a positive correlation between the amplitude of N30 and the simple visual reaction time [7].
  • The phosphatases P7-P11 were found to be effective in the dephosphorylation of Alzheimer's disease abnormally hyperphosphorylated tau [8].
  • A case of schizophrenia-like psychosis (psychotic disorder not otherwise specified according to the DSM-IV criteria) with pericentric inversion on chromosome 9 [inv.(9) (p11; q13)] is reported [9].
  • In a series of 127 children diagnosed with autistic disorder the karyotypes of 8, on whom data were available, showed the following chromosomal abnormalities: breakage, a 47 XY pattern, trisomy 13, inversion-duplication of chromosome 15, 47 XY, +der (15) (pter q15: p11 pter), 47 XXY and 46 XY, inv (2) (p11:q13pat, 3q+) [10].

High impact information on S100A10

  • Immuno-electron microscopy was performed on human monocytes with immunoglobulins recognizing the active (p20) or precursor (p11) domains of ICE [11].
  • Generation of active ICE is affected by the removal of an 11-kD NH2-terminal precursor domain (p11) and an internal 19-amino acid sequence that separates the 20- and 10-kD subunits [11].
  • Whole-cell recording in the superficial layers of the developing superior colliculus (sSC) reveals a large drop in NMDA receptor (NMDAR) current decay time synchronized across all neurons and occurring consistently between P10 and P11 [12].
  • Active ICE proteins, p10 and p20, were demonstrated by immunoblot in lymphocytes from HIV-1-infected patients and in normal lymphocytes after treatment with Fas agonist, CH11 mAb [13].
  • No significant effect on p11 mRNA expression in sigmoid colon or rectum was noted from antidepressant treatment in any of the analyzed subgroups [14].

Chemical compound and disease context of S100A10

  • Phl p 11 was expressed as a soluble fusion protein in Escherichia coli, purified to homogeneity and used for serological analysis and to study Phl p 11 specific induction of histamine release from basophils and skin reactivity in sensitized and control subjects [15].
  • Both the double virus T7/vaccinia hybrid system and the single recombinant strategy based on the p11 K late promoter were evaluated for their ability to govern expression and secretion of recombinant human secretory component (SC), a glycoprotein associated with IgA in mucosal secretions [16].
  • The spin-labeled derivative of podophyllotoxin, N'-podophyllic acid-N-[3-(2,2,5,5-tetramethyl pyrrolinenyloxy)] semicarbazide (GP-11), was synthesized and tested for its antitumor activity against mouse transplantable tumors, Sarcoma-180, Hepatoma-A, P388 leukemia and Ehrlich ascites carcinoma [17].
  • In this in vitro study the effects of a range of concentrations (2-10 microg/ml) of sodium selenite were investigated in one low-passage culture of biopsy-derived glioma cells (IPSB-18, an anaplastic astrocytoma, P 18-22) and a normal human brain cell culture (CC2565, P11) [18].
  • The effects on intragastric p11 and gastrin secretion of once daily pantoprazole (40 mg) and a new formulation omeprazole (20 mg) in a Multiple Unit Pellet System (MUPS) were investigated during two treatment periods of 7 days each in a randomized crossover study with 16 healthy Helicobacter pylori-negative male volunteers [19].

Biological context of S100A10


Anatomical context of S100A10

  • Binding of plasmin to annexin A2 and S100A10 on monocytes was verified by biotin transfer from plasmin labeled with a trifunctional cross-linker [20].
  • Typically, S100A10 is thought to be anchored to the plasma membrane via the phospholipid-binding sites of its binding partner, annexin A2 [1].
  • Whole-mount immunoelectron microscopy of the aberrantly localized recycling endosomes in annexin 2/S100A10 down-regulated cells revealed extensively bent tubules and an increased number of endosome-associated clathrin-positive buds [22].
  • However, these genes were newly expressed in the RCC lesions (n=7) and the RCC cell line, indicating that expression of S100A1 and S100A10 genes is accompanied by RCC [4].
  • p11 expression in human bronchial epithelial cells is increased by nitric oxide in a cGMP-dependent pathway involving protein kinase G activation [23].

Associations of S100A10 with chemical compounds

  • Of these five amino acids, the first threonine plays a crucial role since the corresponding mutants (TRPV5 T599A and TRPV6 T600A) exhibited a diminished capacity to bind S100A10, were redistributed to a subplasma membrane area and did not display channel activity [24].
  • Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer [25].
  • Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells [26].
  • Temperature stress-induced annexin 2 translocation is dependent on both expression of protein p11 (S100A10) and tyrosine phosphorylation of annexin 2 because annexin 2 release is completely eliminated on depletion of p11, inactivation of tyrosine kinase, or mutation of tyrosine 23 [27].
  • Annexin II heterotetramer (AIIt) is a Ca(2+)- and phospholipid-binding protein that consists of two copies of a p36 and p11 subunit [28].

Physical interactions of S100A10

  • To identify components that could regulate differentially the release of pro- and antithrombogenic factors, we analyzed the contribution of Rab3D and the annexin A2/S100A10 complex, proteins implicated in exocytotic events in other systems [29].
  • The S100A10 subunit bound t-PA (Kd = 0.45 microm), plasminogen (Kd = 1.81 microm), and plasmin (Kd = 0.36 microm) [21].

Co-localisations of S100A10


Regulatory relationships of S100A10


Other interactions of S100A10

  • Removal of the carboxyl-terminal lysines from the S100A10 subunit attenuated t-PA and plasminogen binding to AIIt [21].
  • Comparison of the differentially expressed genes with DNA copy number changes in Karpas299 revealed that two overexpressed genes, S100A10 and S100A11, were located in an amplicon suggesting that the increased mRNA levels were caused by DNA amplification [3].
  • Using S100A10 as new bait, a specific interaction with S100A7 was detectable [33].
  • Annexin A2-S100A10 heterotetramer, a novel substrate of thioredoxin [34].
  • In addition, S100A10 knock-down cells demonstrate a dramatic loss in extracellular matrix degradation and invasiveness as well as reduced metastasis [5].

Analytical, diagnostic and therapeutic context of S100A10


  1. RNA interference-mediated silencing of the S100A10 gene attenuates plasmin generation and invasiveness of Colo 222 colorectal cancer cells. Zhang, L., Fogg, D.K., Waisman, D.M. J. Biol. Chem. (2004) [Pubmed]
  2. Cluster analysis of S100 gene expression and genes correlating to psoriasin (S100A7) expression at different stages of breast cancer development. Carlsson, H., Petersson, S., Enerbäck, C. Int. J. Oncol. (2005) [Pubmed]
  3. High expression of calcium-binding proteins, S100A10, S100A11 and CALM2 in anaplastic large cell lymphoma. Rust, R., Visser, L., van der Leij, J., Harms, G., Blokzijl, T., Deloulme, J.C., van der Vlies, P., Kamps, W., Kok, K., Lim, M., Poppema, S., van den Berg, A. Br. J. Haematol. (2005) [Pubmed]
  4. Induced transcriptional expression of calcium-binding protein S100A1 and S100A10 genes in human renal cell carcinoma. Teratani, T., Watanabe, T., Kuwahara, F., Kumagai, H., Kobayashi, S., Aoki, U., Ishikawa, A., Arai, K., Nozawa, R. Cancer Lett. (2002) [Pubmed]
  5. S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors. Kwon, M., MacLeod, T.J., Zhang, Y., Waisman, D.M. Front. Biosci. (2005) [Pubmed]
  6. Genomic organisation of the approximately 1.5 Mb Smith-Magenis syndrome critical interval: transcription map, genomic contig, and candidate gene analysis. Lucas, R.E., Vlangos, C.N., Das, P., Patel, P.I., Elsea, S.H. Eur. J. Hum. Genet. (2001) [Pubmed]
  7. Somatosensory-evoked potentials in athletes. Thomas, N.G., Mitchell, D. Medicine and science in sports and exercise. (1996) [Pubmed]
  8. Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities. Cheng, L.Y., Wang, J.Z., Gong, C.X., Pei, J.J., Zaidi, T., Grundke-Iqbal, I., Iqbal, K. Neurochem. Res. (2001) [Pubmed]
  9. A case of small cerebral cyst and pericentric inversion of chromosome 9 that developed schizophrenia-like psychosis. Miyaoka, T., Seno, H., Itoga, M., Ishino, H. Psychiatry and clinical neurosciences. (1999) [Pubmed]
  10. Chromosomal abnormalities in a series of children with autistic disorder. Konstantareas, M.M., Homatidis, S. Journal of autism and developmental disorders. (1999) [Pubmed]
  11. The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. Singer, I.I., Scott, S., Chin, J., Bayne, E.K., Limjuco, G., Weidner, J., Miller, D.K., Chapman, K., Kostura, M.J. J. Exp. Med. (1995) [Pubmed]
  12. Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents. Shi, J., Townsend, M., Constantine-Paton, M. Neuron (2000) [Pubmed]
  13. The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection. Sloand, E.M., Maciejewski, J.P., Sato, T., Bruny, J., Kumar, P., Kim, S., Weichold, F.F., Young, N.S. J. Clin. Invest. (1998) [Pubmed]
  14. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Camilleri, M., Andrews, C.N., Bharucha, A.E., Carlson, P.J., Ferber, I., Stephens, D., Smyrk, T.C., Urrutia, R., Aerssens, J., Thielemans, L., Göhlmann, H., van den Wyngaert, I., Coulie, B. Gastroenterology (2007) [Pubmed]
  15. Molecular and immunological characterization of a novel timothy grass (Phleum pratense) pollen allergen, Phl p 11. Marknell DeWitt, A., Niederberger, V., Lehtonen, P., Spitzauer, S., Sperr, W.R., Valent, P., Valenta, R., Lidholm, J. Clin. Exp. Allergy (2002) [Pubmed]
  16. Cellular processing limits the heterologous expression of secretory component in mammalian cells. Cottet, S., Corthésy, B. Eur. J. Biochem. (1997) [Pubmed]
  17. Antitumor activity of a new low immunosuppressive derivative of podophyllotoxin (GP-11) and its mechanisms. Wang, J.Z., Tian, X., Tsumura, H., Shimura, K., Ito, H. Anticancer Drug Des. (1993) [Pubmed]
  18. Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Rooprai, H.K., Kyriazis, I., Nuttall, R.K., Edwards, D.R., Zicha, D., Aubyn, D., Davies, D., Gullan, R., Pilkington, G.J. Int. J. Oncol. (2007) [Pubmed]
  19. Comparison of the pharmacodynamics and pharmacokinetics of pantoprazole (40 mg) as compared to omeprazole MUPS (20 mg) after repeated oral dose administration. Ehrlich, A., Lücker, P.W., Wiedemann, A., Sander, P., Huber, R., Mascher, H. Methods and findings in experimental and clinical pharmacology. (1999) [Pubmed]
  20. Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes. Laumonnier, Y., Syrovets, T., Burysek, L., Simmet, T. Blood (2006) [Pubmed]
  21. Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin. MacLeod, T.J., Kwon, M., Filipenko, N.R., Waisman, D.M. J. Biol. Chem. (2003) [Pubmed]
  22. The annexin 2/S100A10 complex controls the distribution of transferrin receptor-containing recycling endosomes. Zobiack, N., Rescher, U., Ludwig, C., Zeuschner, D., Gerke, V. Mol. Biol. Cell (2003) [Pubmed]
  23. p11 expression in human bronchial epithelial cells is increased by nitric oxide in a cGMP-dependent pathway involving protein kinase G activation. Pawliczak, R., Cowan, M.J., Huang, X., Nanavaty, U.B., Alsaaty, S., Logun, C., Shelhamer, J.H. J. Biol. Chem. (2001) [Pubmed]
  24. Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. van de Graaf, S.F., Hoenderop, J.G., Gkika, D., Lamers, D., Prenen, J., Rescher, U., Gerke, V., Staub, O., Nilius, B., Bindels, R.J. EMBO J. (2003) [Pubmed]
  25. Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. Gokhale, N.A., Abraham, A., Digman, M.A., Gratton, E., Cho, W. J. Biol. Chem. (2005) [Pubmed]
  26. Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells. Huang, X.L., Pawliczak, R., Cowan, M.J., Gladwin, M.T., Madara, P., Logun, C., Shelhamer, J.H. J. Biol. Chem. (2002) [Pubmed]
  27. An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface. Deora, A.B., Kreitzer, G., Jacovina, A.T., Hajjar, K.A. J. Biol. Chem. (2004) [Pubmed]
  28. Identification of annexin II heterotetramer as a plasmin reductase. Kwon, M., Caplan, J.F., Filipenko, N.R., Choi, K.S., Fitzpatrick, S.L., Zhang, L., Waisman, D.M. J. Biol. Chem. (2002) [Pubmed]
  29. Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. Knop, M., Aareskjold, E., Bode, G., Gerke, V. EMBO J. (2004) [Pubmed]
  30. CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis. Kirshner, J., Schumann, D., Shively, J.E. J. Biol. Chem. (2003) [Pubmed]
  31. Interferon-gamma induces p11 gene and protein expression in human epithelial cells through interferon-gamma-activated sequences in the p11 promoter. Huang, X.L., Pawliczak, R., Yao, X.L., Cowan, M.J., Gladwin, M.T., Walter, M.J., Holtzman, M.J., Madara, P., Logun, C., Shelhamer, J.H. J. Biol. Chem. (2003) [Pubmed]
  32. The p11 subunit of the annexin II tetramer plays a key role in the stimulation of t-PA-dependent plasminogen activation. Kassam, G., Le, B.H., Choi, K.S., Kang, H.M., Fitzpatrick, S.L., Louie, P., Waisman, D.M. Biochemistry (1998) [Pubmed]
  33. Detection and identification of protein interactions of S100 proteins by ProteinChip technology. Lehmann, R., Melle, C., Escher, N., von Eggeling, F. J. Proteome Res. (2005) [Pubmed]
  34. Annexin A2-S100A10 heterotetramer, a novel substrate of thioredoxin. Kwon, M., Yoon, C.S., Jeong, W., Rhee, S.G., Waisman, D.M. J. Biol. Chem. (2005) [Pubmed]
  35. Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family. Harder, T., Kube, E., Gerke, V. Gene (1992) [Pubmed]
  36. Protein-protein interaction studied by site-directed mutagenesis. Characterization of the annexin II-binding site on p11, a member of the S100 protein family. Kube, E., Becker, T., Weber, K., Gerke, V. J. Biol. Chem. (1992) [Pubmed]
  37. Thrombin induces endothelial cell-surface exposure of the plasminogen receptor annexin 2. Peterson, E.A., Sutherland, M.R., Nesheim, M.E., Pryzdial, E.L. J. Cell. Sci. (2003) [Pubmed]
WikiGenes - Universities