Disease relevance of SCG2

• The distribution of secretoneurin (SN), a peptide derived from secretogranin II (SgII), in the coeliac ganglion, the splenic nerve and the spleen was examined by immunohistochemistry [1].

High impact information on SCG2

• The processing of secretogranin II in the peripheral nervous system: release of secretoneurin from porcine sympathetic nerve terminals [1].
• To evaluate the processing of SgII in sympathetic neurons, boiled tissue extracts (coeliac ganglia and splenic nerve) and boiled spleen perfusate (used as a suitable source for vesicle derived peptides) were analysed by gel filtration chromatography followed by SN-RIA [1].
• Aminergic endocrine cells (e.g., enterochromaffin and enterochromaffin-like cells) regularly exhibited strong immunoreactivities for CgA but failed to react for SgII [2].
• In addition, a copurifying peptide was identified as an NH2-terminal related fragment of the secretogranin II molecule [3].
• Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts [3].

Anatomical context of SCG2

• Secretory granules of endocrine cells contain one or more of the acidic secretory proteins chromogranin A (secretory protein-I), chromogranin B (secretogranin I), and secretogranin II (chromogranin C) [4].

References