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Gene Review:

Rab27a - RAB27A, member RAS oncogene family

Rattus norvegicus

Synonyms: GTP-binding protein Ram, Rab-27, Rab27, Ram p25, Ras-related protein Rab-27A

Waselle, L. et al., Nashida, T. et al., Goishi, K. et al.

Nashida, Imai, Shimomura,

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High impact information on Rab27a

Selective reduction of Rab27a expression by RNA interference did not alter granule distribution and basal secretion but impaired exocytosis triggered by insulin secretagogues [1].
Rab27a is a GTPase associated with insulin-containing secretory granules of pancreatic beta-cells [1].
Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells [2].
Rab26 and two other type III Rab proteins, Rab3D and Rab27, were present in the mature granule membrane fraction [3].

References

Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis. Waselle, L., Coppola, T., Fukuda, M., Iezzi, M., El-Amraoui, A., Petit, C., Regazzi, R. Mol. Biol. Cell (2003) [Pubmed]
Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells. Goishi, K., Mizuno, K., Nakanishi, H., Sasaki, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Relation of Rab26 to the amylase release from rat parotid acinar cells. Nashida, T., Imai, A., Shimomura, H. Arch. Oral Biol. (2006) [Pubmed]

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RAB27A	Bos taurus
aex-6	Caenorhabditis elegans
RAB27A	Canis lupus familiaris
rab27a	Danio rerio
Rab27	Drosophila melanogaster
RAB27A	Gallus gallus
RAB27A	Homo sapiens
RAB27A	Macaca mulatta
Rab27a	Mus musculus
RAB27A	Pan troglodytes
rab27a	Xenopus (Silurana) tropicalis

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