Gene Review:
Rab27a - RAB27A, member RAS oncogene family
Mus musculus
Synonyms:
2210402C08Rik, 2410003M20Rik, 4933437C11Rik, Ras-related protein Rab-27A, ash
- Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. Kasai, K., Ohara-Imaizumi, M., Takahashi, N., Mizutani, S., Zhao, S., Kikuta, T., Kasai, H., Nagamatsu, S., Gomi, H., Izumi, T. J. Clin. Invest. (2005)
- Rab27a regulates the peripheral distribution of melanosomes in melanocytes. Hume, A.N., Collinson, L.M., Rapak, A., Gomes, A.Q., Hopkins, C.R., Seabra, M.C. J. Cell Biol. (2001)
- The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background. Novak, E.K., Gautam, R., Reddington, M., Collinson, L.M., Copeland, N.G., Jenkins, N.A., McGarry, M.P., Swank, R.T. Blood (2002)
- Mouse genetic corneal disease resulting from transgenic insertional mutagenesis. Ramalho, J.S., Gregory-Evans, K., Huxley, C., Seabra, M.C. The British journal of ophthalmology. (2004)
- Delivering the kiss of death. Trambas, C.M., Griffiths, G.M. Nat. Immunol. (2003)
- Identification of an organelle receptor for myosin-Va. Wu, X.S., Rao, K., Zhang, H., Wang, F., Sellers, J.R., Matesic, L.E., Copeland, N.G., Jenkins, N.A., Hammer, J.A. Nat. Cell Biol. (2002)
- The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Futter, C.E., Ramalho, J.S., Jaissle, G.B., Seeliger, M.W., Seabra, M.C. Mol. Biol. Cell (2004)
- Rab7 and Rab27a control two motor protein activities involved in melanosomal transport. Jordens, I., Westbroek, W., Marsman, M., Rocha, N., Mommaas, M., Huizing, M., Lambert, J., Naeyaert, J.M., Neefjes, J. Pigment Cell Res. (2006)
- Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome. Bahadoran, P., Busca, R., Chiaverini, C., Westbroek, W., Lambert, J., Bille, K., Valony, G., Fukuda, M., Naeyaert, J.M., Ortonne, J.P., Ballotti, R. J. Biol. Chem. (2003)
- Rab27a is required for regulated secretion in cytotoxic T lymphocytes. Stinchcombe, J.C., Barral, D.C., Mules, E.H., Booth, S., Hume, A.N., Machesky, L.M., Seabra, M.C., Griffiths, G.M. J. Cell Biol. (2001)
- Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice. Matesic, L.E., Yip, R., Reuss, A.E., Swing, D.A., O'Sullivan, T.N., Fletcher, C.F., Copeland, N.G., Jenkins, N.A. Proc. Natl. Acad. Sci. U.S.A. (2001)
- A role for Rab27b in NF-E2-dependent pathways of platelet formation. Tiwari, S., Italiano, J.E., Barral, D.C., Mules, E.H., Novak, E.K., Swank, R.T., Seabra, M.C., Shivdasani, R.A. Blood (2003)
- The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Hume, A.N., Collinson, L.M., Hopkins, C.R., Strom, M., Barral, D.C., Bossi, G., Griffiths, G.M., Seabra, M.C. Traffic (2002)
- Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients. Menasche, G., Feldmann, J., Houdusse, A., Desaymard, C., Fischer, A., Goud, B., de Saint Basile, G. Blood (2003)
- The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Yi, Z., Yokota, H., Torii, S., Aoki, T., Hosaka, M., Zhao, S., Takata, K., Takeuchi, T., Izumi, T. Mol. Cell. Biol. (2002)
- The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines. Kimura, T., Kaneko, Y., Yamada, S., Ishihara, H., Senda, T., Iwamatsu, A., Niki, I. J. Cell. Sci. (2008)
- Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. Figueiredo, A.C., Wasmeier, C., Tarafder, A.K., Ramalho, J.S., Baron, R.A., Seabra, M.C. J. Biol. Chem. (2008)
- Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes. Gibbs, D., Azarian, S.M., Lillo, C., Kitamoto, J., Klomp, A.E., Steel, K.P., Libby, R.T., Williams, D.S. J. Cell. Sci. (2004)
- The acroplaxome is the docking site of Golgi-derived myosin Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatids. Kierszenbaum, A.L., Tres, L.L., Rivkin, E., Kang-Decker, N., van Deursen, J.M. Biol. Reprod. (2004)
- Granuphilin molecularly docks insulin granules to the fusion machinery. Gomi, H., Mizutani, S., Kasai, K., Itohara, S., Izumi, T. J. Cell Biol. (2005)
- Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. Larijani, B., Hume, A.N., Tarafder, A.K., Seabra, M.C. J. Biol. Chem. (2003)