Gene Review:
AMFR - autocrine motility factor receptor, E3...
Bos taurus
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High impact information on AMFR
- Ilimaquinone (IQ) is a sea sponge metabolite which induces the complete vesiculation of the Golgi apparatus and we show here that the addition of IQ to MDCK cells also results in the disruption of the AMF-R tubule [1].
- The AMF-R tubule is a smooth ilimaquinone-sensitive subdomain of the endoplasmic reticulum [1].
- By immunofluorescence microscopy, the resultant punctate AMF-R label resembles the products of IQ-mediated vesiculation of the trans-Golgi network, however, the two labels can be distinguished by confocal microscopy [1].
- AMF-R tubule fragmentation occurs after nocodazole or taxol treatment of the cells demonstrating that the action of IQ on AMF-R tubules is not related to the ability of IQ to depolymerize microtubules [1].
Analytical, diagnostic and therapeutic context of AMFR
- AMF-R tubules can be distinguished from the intermediate compartment labeled for ERGIC-53 by confocal microscopy and thus constitute a distinct IQ-sensitive subdomain of the smooth ER [1].
- Electron microscopy of IQ-treated cells reveals that AMF-R is distributed to fenestrated networks of narrow interconnected tubules which are distinguishable from the uniform Golgi-derived vesicles and morphologically equivalent to smooth ER [1].
References
- The AMF-R tubule is a smooth ilimaquinone-sensitive subdomain of the endoplasmic reticulum. Wang, H.J., Benlimame, N., Nabi, I. J. Cell. Sci. (1997) [Pubmed]
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