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Chemical Compound Review

Oncodazole     methylN-(6-thiophen-2- ylcarbonyl-1H...

Synonyms: Nocodazol, Nocidazole, nocodazole, NSC-238159, NSC238159, ...
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Disease relevance of R 17934


Psychiatry related information on R 17934


High impact information on R 17934

  • Fragmentation of the Golgi apparatus by nocodazole or Brefeldin A treatment prior to or post microinjection of the anti-GRASP65 antibody alleviated the block in mitotic entry [7].
  • The percent of centromeres with microtubule-binding activity is 7- to 10-fold higher in lysates made from nocodazole-arrested G2-M cells than from alpha factor G1 cells, suggesting that this centromere activity is regulated during the cell cycle [8].
  • In mutant zygotes with abnormal spindle orientations and in wild-type zygotes treated with the microtubule inhibitors nocodazole, colcemid, vinblastine, and griseofulvin, both P-granule segregation to the posterior pole and the concomitant pseudocleavage occur apparently normally, but the normally concurrent migration of the pronuclei is inhibited [9].
  • Cells with neurites are incubated with the microtubule-depolymerizing drug Nocodazole [10].
  • In the presence of the gamma-tubulin antibody, microtubules fail to regrow into cytoplasmic arrays after depolymerization induced by nocodazole or cold [11].

Chemical compound and disease context of R 17934


Biological context of R 17934


Anatomical context of R 17934


Associations of R 17934 with other chemical compounds

  • Phagosome-phagosome fusion required bacterial protein synthesis and intact host microtubules, and both chloramphenicol and nocodazole increased killing of intracellular H. pylori [25].
  • Constitutive IGF-II-expressing cells actively incorporated thymidine and showed an increase in the proportion of cells with >4N DNA ploidy in the presence of nocodazole [26].
  • METHODS: Confocal microscopy and image analysis were performed to quantitatively assess changes in secretory capacity and vesicle targeting in isolated rat hepatocyte couplets that had been exposed to fluorescent bile acid after pretreatment with dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP) and/or nocodazole [27].
  • Glu tubulin injected into nocodazole-treated cells was converted to Tyr tubulin by a putative tubulin/tyrosine ligase activity [28].
  • Finally, we have found that expression of human gamma-tubulin or overexpression of S. pombe gamma-tubulin causes no significant alteration of resistance to the antimicrotubule agents benomyl, thiabendazole and nocodazole [29].

Gene context of R 17934


Analytical, diagnostic and therapeutic context of R 17934


  1. Identification of a human mitotic checkpoint gene: hsMAD2. Li, Y., Benezra, R. Science (1996) [Pubmed]
  2. Species-specific differences in toxicity of antimitotic agents toward cultured mammalian cells. Gupta, R.S. J. Natl. Cancer Inst. (1985) [Pubmed]
  3. Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta. Krylova, O., Messenger, M.J., Salinas, P.C. J. Cell Biol. (2000) [Pubmed]
  4. Nocodazole, a microtubule-active drug, interferes with apical protein delivery in cultured intestinal epithelial cells (Caco-2). Eilers, U., Klumperman, J., Hauri, H.P. J. Cell Biol. (1989) [Pubmed]
  5. Uncoupling of basal body duplication and cell division in crochu, a mutant of Paramecium hypersensitive to nocodazole. Jerka-Dziadosz, M., Ruiz, F., Beisson, J. Development (1998) [Pubmed]
  6. Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. Burkhardt, J.K., Echeverri, C.J., Nilsson, T., Vallee, R.B. J. Cell Biol. (1997) [Pubmed]
  7. Fragmentation and dispersal of the pericentriolar Golgi complex is required for entry into mitosis in mammalian cells. Sütterlin, C., Hsu, P., Mallabiabarrena, A., Malhotra, V. Cell (2002) [Pubmed]
  8. Centromere-dependent binding of yeast minichromosomes to microtubules in vitro. Kingsbury, J., Koshland, D. Cell (1991) [Pubmed]
  9. Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos. Strome, S., Wood, W.B. Cell (1983) [Pubmed]
  10. Neuroblastoma cells recapitulate their detailed neurite morphologies after reversible microtubule disassembly. Solomon, F. Cell (1980) [Pubmed]
  11. Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. Joshi, H.C., Palacios, M.J., McNamara, L., Cleveland, D.W. Nature (1992) [Pubmed]
  12. Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis. Litchfield, D.W., Lüscher, B., Lozeman, F.J., Eisenman, R.N., Krebs, E.G. J. Biol. Chem. (1992) [Pubmed]
  13. Ornithine decarboxylase expression leads to translocation and activation of protein kinase CK2 in vivo. Shore, L.J., Soler, A.P., Gilmour, S.K. J. Biol. Chem. (1997) [Pubmed]
  14. Expression of de-N-acetyl-gangliosides in human melanoma cells is induced by genistein or nocodazole. Sjoberg, E.R., Chammas, R., Ozawa, H., Kawashima, I., Khoo, K.H., Morris, H.R., Dell, A., Tai, T., Varki, A. J. Biol. Chem. (1995) [Pubmed]
  15. Sec15 is an effector for the Rab11 GTPase in mammalian cells. Zhang, X.M., Ellis, S., Sriratana, A., Mitchell, C.A., Rowe, T. J. Biol. Chem. (2004) [Pubmed]
  16. The effect of colchicine and dibucaine on the morphogenesis of Semliki Forest virus. Richardson, C.D., Vance, D.E. J. Biol. Chem. (1978) [Pubmed]
  17. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest. Takenaka, K., Moriguchi, T., Nishida, E. Science (1998) [Pubmed]
  18. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Chen, R.H., Waters, J.C., Salmon, E.D., Murray, A.W. Science (1996) [Pubmed]
  19. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Aylon, Y., Michael, D., Shmueli, A., Yabuta, N., Nojima, H., Oren, M. Genes Dev. (2006) [Pubmed]
  20. Microtubule binding to Smads may regulate TGF beta activity. Dong, C., Li, Z., Alvarez, R., Feng, X.H., Goldschmidt-Clermont, P.J. Mol. Cell (2000) [Pubmed]
  21. Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents. Ding, A.H., Porteu, F., Sanchez, E., Nathan, C.F. J. Exp. Med. (1990) [Pubmed]
  22. Lens epithelial cell elongation in the absence of microtubules: evidence for a new effect of colchicine. Beebe, D.C., Feagans, D.E., Blanchette-Mackie, E.J., Nau, M.E. Science (1979) [Pubmed]
  23. Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages. Racoosin, E.L., Swanson, J.A. J. Exp. Med. (1989) [Pubmed]
  24. G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. Blajeski, A.L., Phan, V.A., Kottke, T.J., Kaufmann, S.H. J. Clin. Invest. (2002) [Pubmed]
  25. Virulent strains of Helicobacter pylori demonstrate delayed phagocytosis and stimulate homotypic phagosome fusion in macrophages. Allen, L.A., Schlesinger, L.S., Kang, B. J. Exp. Med. (2000) [Pubmed]
  26. Cell cycle block at G1-S or G2-M phase correlates with differentiation of Caco-2 cells: effect of constitutive insulin-like growth factor II expression. Zarrilli, R., Pignata, S., Apicella, A., Di Popolo, A., Memoli, A., Ricchi, P., Salzano, S., Acquaviva, A.M. Gastroenterology (1999) [Pubmed]
  27. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Boyer, J.L., Soroka, C.J. Gastroenterology (1995) [Pubmed]
  28. Assembly and turnover of detyrosinated tubulin in vivo. Webster, D.R., Gundersen, G.G., Bulinski, J.C., Borisy, G.G. J. Cell Biol. (1987) [Pubmed]
  29. Human gamma-tubulin functions in fission yeast. Horio, T., Oakley, B.R. J. Cell Biol. (1994) [Pubmed]
  30. Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Pan, J., Chen, R.H. Genes Dev. (2004) [Pubmed]
  31. Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans. Kitagawa, R., Rose, A.M. Nat. Cell Biol. (1999) [Pubmed]
  32. Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. Ookata, K., Hisanaga, S., Bulinski, J.C., Murofushi, H., Aizawa, H., Itoh, T.J., Hotani, H., Okumura, E., Tachibana, K., Kishimoto, T. J. Cell Biol. (1995) [Pubmed]
  33. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. Hoogenraad, C.C., Akhmanova, A., Howell, S.A., Dortland, B.R., De Zeeuw, C.I., Willemsen, R., Visser, P., Grosveld, F., Galjart, N. EMBO J. (2001) [Pubmed]
  34. The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. Janke, C., Ortiz, J., Lechner, J., Shevchenko, A., Shevchenko, A., Magiera, M.M., Schramm, C., Schiebel, E. EMBO J. (2001) [Pubmed]
  35. Effect of microtubule inhibitors on malignant invasion in vitro. Mareel, M.M., De Brabander, M.J. J. Natl. Cancer Inst. (1978) [Pubmed]
  36. Functions of microtubules in the Saccharomyces cerevisiae cell cycle. Jacobs, C.W., Adams, A.E., Szaniszlo, P.J., Pringle, J.R. J. Cell Biol. (1988) [Pubmed]
  37. Secretion of invertase in mitotic yeast cells. Makarow, M. EMBO J. (1988) [Pubmed]
  38. The rubella virus E2 and E1 spike glycoproteins are targeted to the Golgi complex. Hobman, T.C., Woodward, L., Farquhar, M.G. J. Cell Biol. (1993) [Pubmed]
  39. Cell cycle-regulated expression of the muscle determination factor Myf5 in proliferating myoblasts. Lindon, C., Montarras, D., Pinset, C. J. Cell Biol. (1998) [Pubmed]
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