Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

IBD6 - inflammatory bowel disease 6

Homo sapiens

van Heel, D.A. et al., Low, J.H. et al., Tello-Ruiz, M.K. et al.

van Heel, Dechairo, Dawson, McGovern, Negoro, Carey, Cardon, Mackay, Jewell, Lench,

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Disease relevance of IBD6

The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants [1].

High impact information on IBD6

Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19 [2].
Genome-wide scans have implicated several susceptibility loci, but linkage of 19p13 (IBD6) to Crohn's disease (CD) has not been fully replicated [3].
Linkage between IBD6 linkage and CD was replicated (LOD score = 1.59) [3].

Biological context of IBD6

Evidence for linkage to chromosome 19 (IBD6) was observed in Crohn's disease pairs not possessing CARD15 mutations (P=0.0001), and in pairs possessing one or two copies of the IBD5 risk haplotype (P=0.0005), with significant evidence for genetic heterogeneity and epistasis, respectively [1].

References

The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants. van Heel, D.A., Dechairo, B.M., Dawson, G., McGovern, D.P., Negoro, K., Carey, A.H., Cardon, L.R., Mackay, I., Jewell, D.P., Lench, N.J. Hum. Mol. Genet. (2003) [Pubmed]
Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19. Tello-Ruiz, M.K., Curley, C., DelMonte, T., Giallourakis, C., Kirby, A., Miller, K., Wild, G., Cohen, A., Langelier, D., Latiano, A., Wedemeyer, N., Lander, E., Schreiber, S., Annese, V., Daly, M.J., Rioux, J.D. Eur. J. Hum. Genet. (2006) [Pubmed]
Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. Low, J.H., Williams, F.A., Yang, X., Cullen, S., Colley, J., Ling, K.L., Armuzzi, A., Ahmad, T., Neville, M.J., Dechairo, B.M., Walton, R., Lench, N.J., Jewell, D.P. Inflamm. Bowel Dis. (2004) [Pubmed]

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