The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

IBD5  -  inflammatory bowel disease 5

Homo sapiens

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IBD5


High impact information on IBD5


Chemical compound and disease context of IBD5


Biological context of IBD5

  • These genes encode solute carriers and the association was suggested to be distinct from the background IBD5 risk haplotype [1].
  • There was no deviation from a multiplicative model of interaction between CARD15 and IBD5 on the penetrance scale [1].
  • Recently, two polymorphisms in the organic cation transporter (OCTN) gene cluster within the IBD5 locus have been found to be associated with CD [2].
  • The frequency of the IBD5 homozygous mutant genotype significantly increased in CD patients lacking response to infliximab (RR = 3.88, 95% CI = 1.18-12.0, P<0.05) [8].
  • The kind of interaction, either genetic heterogeneity or epistasis, between this IBD5 susceptibility region and the NOD2/CARD15 gene mutations was studied as well [8].

Other interactions of IBD5

  • There have been conflicting reports of the association between markers in the IBD5 region and ulcerative colitis (UC) and interaction (epistasis) between this locus and CARD15 [1].
  • Although OCTN variants may account for the increased risk of IBD associated with IBD5, a role for other candidate genes within this extended haplotype was not excluded [1].
  • Evidence is also given for potential interactions between CARD15and IBD2/IBD5 [9].
  • The carnitine/organic cation transporter (OCTN) on 5q31 (IBD5) is associated with Crohn's disease (CD) and DLG5 (10q23), a member of membrane-associated guanylate kinase (MAGUK) family, with IBD [10].


  1. Evidence for association of OCTN genes and IBD5 with ulcerative colitis. Waller, S., Tremelling, M., Bredin, F., Godfrey, L., Howson, J., Parkes, M. Gut (2006) [Pubmed]
  2. Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease. Babusukumar, U., Wang, T., McGuire, E., Broeckel, U., Kugathasan, S. Am. J. Gastroenterol. (2006) [Pubmed]
  3. Contribution of IBD5 locus to clinical features of IBD patients. Latiano, A., Palmieri, O., Valvano, R.M., D'Incà, R., Vecchi, M., Ferraris, A., Sturniolo, G.C., Spina, L., Lombardi, G., Dallapiccola, B., Andriulli, A., Devoto, M., Annese, V. Am. J. Gastroenterol. (2006) [Pubmed]
  4. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Peltekova, V.D., Wintle, R.F., Rubin, L.A., Amos, C.I., Huang, Q., Gu, X., Newman, B., Van Oene, M., Cescon, D., Greenberg, G., Griffiths, A.M., St George-Hyslop, P.H., Siminovitch, K.A. Nat. Genet. (2004) [Pubmed]
  5. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Rioux, J.D., Daly, M.J., Silverberg, M.S., Lindblad, K., Steinhart, H., Cohen, Z., Delmonte, T., Kocher, K., Miller, K., Guschwan, S., Kulbokas, E.J., O'Leary, S., Winchester, E., Dewar, K., Green, T., Stone, V., Chow, C., Cohen, A., Langelier, D., Lapointe, G., Gaudet, D., Faith, J., Branco, N., Bull, S.B., McLeod, R.S., Griffiths, A.M., Bitton, A., Greenberg, G.R., Lander, E.S., Siminovitch, K.A., Hudson, T.J. Nat. Genet. (2001) [Pubmed]
  6. The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease. Noble, C.L., Nimmo, E.R., Drummond, H., Ho, G.T., Tenesa, A., Smith, L., Anderson, N., Arnott, I.D., Satsangi, J. Gastroenterology (2005) [Pubmed]
  7. A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5). Lamhonwah, A.M., Skaug, J., Scherer, S.W., Tein, I. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  8. IBD5 polymorphisms in inflammatory bowel disease: association with response to infliximab. Urcelay, E., Mendoza, J.L., Martinez, A., Fernandez, L., Taxonera, C., Diaz-Rubio, M., de la Concha, E.G. World J. Gastroenterol. (2005) [Pubmed]
  9. Characterization of genotype-phenotype relationships and stratification by the CARD15 variant genotype for inflammatory bowel disease susceptibility loci using multiple short tandem repeat genetic markers. Crawford, N.P., Colliver, D.W., Funke, A.A., Young, M.N., Kelley, S., Cobbs, G.A., Petras, R.E., Galandiuk, S. Hum. Mutat. (2005) [Pubmed]
  10. Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD. Vermeire, S., Pierik, M., Hlavaty, T., Claessens, G., van Schuerbeeck, N., Joossens, S., Ferrante, M., Henckaerts, L., Bueno de Mesquita, M., Vlietinck, R., Rutgeerts, P. Gastroenterology (2005) [Pubmed]
WikiGenes - Universities