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FPEVF  -  Epilepsy, partial, with variable foci

Homo sapiens

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Disease relevance of FPEVF

  • We identified two large French-Canadian families segregating a familial partial epilepsy syndrome with variable foci (FPEVF) characterized by mostly nocturnal seizures arising from frontal, temporal, and occasionally occipital epileptic foci [1].
  • PURPOSE: Three forms of idiopathic partial epilepsy with autosomal dominant inheritance have been described: (a) autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); (b) autosomal dominant lateral temporal epilepsy (ADLTE) or partial epilepsy with auditory features (ADPEAF); and (c) familial partial epilepsy with variable foci (FPEVF) [2].

High impact information on FPEVF


Analytical, diagnostic and therapeutic context of FPEVF

  • The frequent occurrence of seizures during daytime and the observation of interictal EEG abnormalities originating from different cortical areas were more in agreement with FPEVF [2].


  1. Mapping of a gene determining familial partial epilepsy with variable foci to chromosome 22q11-q12. Xiong, L., Labuda, M., Li, D.S., Hudson, T.J., Desbiens, R., Patry, G., Verret, S., Langevin, P., Mercho, S., Seni, M.H., Scheffer, I., Dubeau, F., Berkovic, S.F., Andermann, F., Andermann, E., Pandolfo, M. Am. J. Hum. Genet. (1999) [Pubmed]
  2. Familial partial epilepsy with variable foci in a Dutch family: clinical characteristics and confirmation of linkage to chromosome 22q. Callenbach, P.M., van den Maagdenberg, A.M., Hottenga, J.J., van den Boogerd, E.H., de Coo, R.F., Lindhout, D., Frants, R.R., Sandkuijl, L.A., Brouwer, O.F. Epilepsia (2003) [Pubmed]
  3. Genetic focal epilepsies: state of the art and paths to the future. Andermann, F., Kobayashi, E., Andermann, E. Epilepsia (2005) [Pubmed]
  4. Familial partial epilepsy with variable foci: clinical features and linkage to chromosome 22q12. Berkovic, S.F., Serratosa, J.M., Phillips, H.A., Xiong, L., Andermann, E., Díaz-Otero, F., Gómez-Garre, P., Martín, M., Fernández-Bullido, Y., Andermann, F., Lopes-Cendes, I., Dubeau, F., Desbiens, R., Scheffer, I.E., Wallace, R.H., Mulley, J.C., Pandolfo, M. Epilepsia (2004) [Pubmed]
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