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MeSH Review

Epilepsies, Partial

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Disease relevance of Epilepsies, Partial


Psychiatry related information on Epilepsies, Partial

  • Subclinical seizure activity may be responsible for a portion of the memory deficits found in patients with epilepsy [6].
  • Results of experiments with novel inhibitors of GABA uptake, which were inactive in the maximal electroshock seizure test but highly potent against kindled seizures, suggest that such drugs might be more effective than current antiepileptic drugs for treatment of partial epilepsy [7].

High impact information on Epilepsies, Partial

  • Here we describe identification of the causative gene in autosomal-dominant partial epilepsy with auditory features (ADPEAF, MIM 600512), a rare form of idiopathic lateral temporal lobe epilepsy characterized by partial seizures with auditory disturbances [8].
  • INTERPRETATION: Vigabatrin seems less effective but better tolerated than carbamazepine, which is the first-choice drug for the treatment of partial epilepsies [9].
  • Thus, the local release of adenosine resulting in adenosine concentrations <25 nM at the site of action is sufficient to suppress seizure activity and, therefore, provides a potential therapeutic principle for the treatment of drug-resistant partial epilepsies [10].
  • We identified two large French-Canadian families segregating a familial partial epilepsy syndrome with variable foci (FPEVF) characterized by mostly nocturnal seizures arising from frontal, temporal, and occasionally occipital epileptic foci [11].
  • Previous imaging studies using 11C-flumazenil in patients with mesial temporal lobe epilepsy and neocortical partial seizure disorders have found focal decreases in gamma-aminobutyric acid type A/benzodiazepine receptor binding [12].

Chemical compound and disease context of Epilepsies, Partial


Biological context of Epilepsies, Partial


Anatomical context of Epilepsies, Partial


Gene context of Epilepsies, Partial


Analytical, diagnostic and therapeutic context of Epilepsies, Partial


  1. Comparison of monotherapy with valproate and other antiepileptic drugs in the treatment of seizure disorders. Chadwick, D. Am. J. Med. (1988) [Pubmed]
  2. Valproate monotherapy in partial seizures. Penry, J.K., Dean, J.C. Am. J. Med. (1988) [Pubmed]
  3. Similar binding to glutamate receptors by Rasmussen and partial epilepsy patients' sera. Bernasconi, P., Cipelletti, B., Passerini, L., Granata, T., Antozzi, C., Mantegazza, R., Spreafico, R. Neurology (2002) [Pubmed]
  4. Long-term follow-up of childhood epilepsy associated with tuberous sclerosis. Ohtsuka, Y., Ohmori, I., Oka, E. Epilepsia (1998) [Pubmed]
  5. Mechanisms of action of valproate: a commentatory. Johannessen, C.U. Neurochem. Int. (2000) [Pubmed]
  6. Memory during subclinical hippocampal seizures. Bridgman, P.A., Malamut, B.L., Sperling, M.R., Saykin, A.J., O'Connor, M.J. Neurology (1989) [Pubmed]
  7. Is amygdala kindling in rats a model for drug-resistant partial epilepsy? Löscher, W., Jäckel, R., Czuczwar, S.J. Exp. Neurol. (1986) [Pubmed]
  8. Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Kalachikov, S., Evgrafov, O., Ross, B., Winawer, M., Barker-Cummings, C., Martinelli Boneschi, F., Choi, C., Morozov, P., Das, K., Teplitskaya, E., Yu, A., Cayanis, E., Penchaszadeh, G., Kottmann, A.H., Pedley, T.A., Hauser, W.A., Ottman, R., Gilliam, T.C. Nat. Genet. (2002) [Pubmed]
  9. Safety and efficacy of vigabatrin and carbamazepine in newly diagnosed epilepsy: a multicentre randomised double-blind study. Vigabatrin European Monotherapy Study Group. Chadwick, D. Lancet (1999) [Pubmed]
  10. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Huber, A., Padrun, V., Déglon, N., Aebischer, P., Möhler, H., Boison, D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  11. Mapping of a gene determining familial partial epilepsy with variable foci to chromosome 22q11-q12. Xiong, L., Labuda, M., Li, D.S., Hudson, T.J., Desbiens, R., Patry, G., Verret, S., Langevin, P., Mercho, S., Seni, M.H., Scheffer, I., Dubeau, F., Berkovic, S.F., Andermann, F., Andermann, E., Pandolfo, M. Am. J. Hum. Genet. (1999) [Pubmed]
  12. Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: an 11C-flumazenil PET study. Richardson, M.P., Koepp, M.J., Brooks, D.J., Fish, D.R., Duncan, J.S. Ann. Neurol. (1996) [Pubmed]
  13. Comparative localization of epileptic foci in partial epilepsy by PCT and EEG. Engel, J., Kuhl, D.E., Phelps, M.E., Crandall, P.H. Ann. Neurol. (1982) [Pubmed]
  14. Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disorders. Hauser, P., Devinsky, O., De Bellis, M., Theodore, W.H., Post, R.M. Arch. Neurol. (1989) [Pubmed]
  15. Sodium valproate and clonazepam in the treatment of intractable epilepsy. Lance, J.W., Anthony, M. Arch. Neurol. (1977) [Pubmed]
  16. Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats. Reissmüller, E., Ebert, U., Löscher, W. Epilepsia (2000) [Pubmed]
  17. Double-blind, placebo-controlled, crossover study of lamotrigine in treatment-resistant generalised epilepsy. Beran, R.G., Berkovic, S.F., Dunagan, F.M., Vajda, F.J., Danta, G., Black, A.B., Mackenzie, R. Epilepsia (1998) [Pubmed]
  18. Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection. Engström, E.R., Hillered, L., Flink, R., Kihlström, L., Lindquist, C., Nie, J.X., Olsson, Y., Silander, H.C. Epilepsy Res. (2001) [Pubmed]
  19. Zif268 and Fos-like immunoreactivity in tetanus toxin-induced epilepsy: reciprocal changes in the epileptic focus and the surround. Liang, F., Jones, E.G. Brain Res. (1997) [Pubmed]
  20. Epileptic seizures and event-related potentials (P300) in childhood partial epilepsies. Naganuma, Y., Konishi, T., Hongou, K., Tohyama, J., Uchiyama, M. Clinical EEG (electroencephalography). (1997) [Pubmed]
  21. Ipsilateral median somatosensory evoked potentials recorded from human somatosensory cortex. Noachtar, S., Lüders, H.O., Dinner, D.S., Klem, G. Electroencephalography and clinical neurophysiology. (1997) [Pubmed]
  22. Comparison of the effects of frontal and temporal lobe partial seizures on prolactin levels. Meierkord, H., Shorvon, S., Lightman, S., Trimble, M. Arch. Neurol. (1992) [Pubmed]
  23. Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats. Seegers, U., Potschka, H., Löscher, W. Epilepsia (2002) [Pubmed]
  24. Neurogenic myocardial arrhythmias in experimental focal epilepsy. Mameli, P., Mameli, O., Tolu, E., Padua, G., Giraudi, D., Caria, M.A., Melis, F. Epilepsia (1988) [Pubmed]
  25. Progress in the genetics of the partial epilepsies. Ottman, R. Epilepsia (2001) [Pubmed]
  26. In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats. Potschka, H., Löscher, W. Epilepsia (2001) [Pubmed]
  27. LGI1 mutations in temporal lobe epilepsies. Berkovic, S.F., Izzillo, P., McMahon, J.M., Harkin, L.A., McIntosh, A.M., Phillips, H.A., Briellmann, R.S., Wallace, R.H., Mazarib, A., Neufeld, M.Y., Korczyn, A.D., Scheffer, I.E., Mulley, J.C. Neurology (2004) [Pubmed]
  28. Neuropeptides: anticonvulsant and convulsant mechanisms in epileptic model systems and in humans. Bajorek, J.G., Lee, R.J., Lomax, P. Advances in neurology. (1986) [Pubmed]
  29. Silent celiac disease in patients with childhood localization-related epilepsies. Labate, A., Gambardella, A., Messina, D., Tammaro, S., Le Piane, E., Pirritano, D., Cosco, C., Doldo, P., Mazzei, R., Oliveri, R.L., Bosco, D., Zappia, M., Valentino, P., Aguglia, U., Quattrone, A. Epilepsia (2001) [Pubmed]
  30. The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies. Blümcke, I., Giencke, K., Wardelmann, E., Beyenburg, S., Kral, T., Sarioglu, N., Pietsch, T., Wolf, H.K., Schramm, J., Elger, C.E., Wiestler, O.D. Acta Neuropathol. (1999) [Pubmed]
  31. Auras and subclinical seizures: characteristics and prognostic significance. Sperling, M.R., O'Connor, M.J. Ann. Neurol. (1990) [Pubmed]
  32. Photosensitive epilepsies and pathophysiologic mechanisms of the photoparoxysmal response. Takahashi, Y., Fujiwara, T., Yagi, K., Seino, M. Neurology (1999) [Pubmed]
  33. Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam. Löscher, W., Hönack, D. Epilepsia (2000) [Pubmed]
  34. Evaluation of focal epilepsy: a SPECT scanning comparison of 123-I-iomazenil versus HM-PAO. Cordes, M., Henkes, H., Ferstl, F., Schmitz, B., Hierholzer, J., Schmidt, D., Felix, R. AJNR. American journal of neuroradiology. (1992) [Pubmed]
  35. A history of Todd and his paralysis. Binder, D.K. Neurosurgery (2004) [Pubmed]
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