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Gene Review:

GOLGA7 - golgin A7

Homo sapiens

Synonyms: GCP16, GOLGA3AP1, GOLGA7A, Golgi complex-associated protein of 16 kDa, Golgin subfamily A member 7, ...

Ohta, E. et al., Swarthout, J.T. et al.

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High impact information on GOLGA7

Here we report that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes [1].
DHHC9 and GCP16 co-distribute in the Golgi apparatus, a location consistent with the site of mammalian Ras palmitoylation in vivo [1].
Immunofluorescence microscopy showed that GCP16 was co-localized with GCP170 and giantin in the Golgi region [2].
Despite the absence of a hydrophobic domain sufficient for participating in membrane localization, GCP16 was found to be tightly associated with membranes like an integral membrane protein [2].
A mutant without potential acylation sites (C69A/C72A) was no longer localized to the Golgi, indicating that the acylation is prerequisite for the Golgi localization of GCP16 [2].

Biological context of GOLGA7

Although the mutant GCP16, even when overexpressed, had no effect on protein transport, overexpression of the wild type GCP16 caused an inhibitory effect on protein transport from the Golgi to the cell surface [2].

Other interactions of GOLGA7

Taken together, these results indicate that GCP16 is the acylated membrane protein, associated with GCP170, and possibly involved in vesicular transport from the Golgi to the cell surface [2].

References

DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. Swarthout, J.T., Lobo, S., Farh, L., Croke, M.R., Greentree, W.K., Deschenes, R.J., Linder, M.E. J. Biol. Chem. (2005) [Pubmed]
Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170. Ohta, E., Misumi, Y., Sohda, M., Fujiwara, T., Yano, A., Ikehara, Y. J. Biol. Chem. (2003) [Pubmed]

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