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Gene Review

CD81  -  CD81 molecule

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Disease relevance of CD81

  • Cell entry of hepatitis C virus, pseudoparticles (HCVpp) and cell culture grown virus (HCVcc), requires the interaction of viral glycoproteins with CD81 and other as yet unknown cellular factors [1].

High impact information on CD81

  • We further demonstrate that tetraspanins CD9, CD81, and CD82 can stabilize their partner protein CD4 [2].


  1. Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. von Hahn, T., Lindenbach, B.D., Boullier, A., Quehenberger, O., Paulson, M., Rice, C.M., McKeating, J.A. Hepatology (2006) [Pubmed]
  2. Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking. Hu, C.C., Liang, F.X., Zhou, G., Tu, L., Tang, C.H., Zhou, J., Kreibich, G., Sun, T.T. Mol. Biol. Cell (2005) [Pubmed]
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