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Gene Review

Cd81  -  CD81 antigen

Mus musculus

Synonyms: 26 kDa cell surface protein TAPA-1, Tapa-1, Tapa1, Target of the antiproliferative antibody 1, Tspan28
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Disease relevance of Cd81


High impact information on Cd81

  • The chromosomal localization on distal chromosome 7 places it in a cluster of imprinted genes, flanked by the previously described Tapa1 and Kcnq1 genes [2].
  • Increased density of retinal pigment epithelium in cd81-/- mice [3].
  • Adult cd81(-/-) mice were produced by crossing two inbred strains, NIHS-BC/Tac and 129X1/SvJ, carrying the cd81 mutation as heterozygotes (+/-) [3].
  • The photoreceptor layer of the cd81(-/-) mice was significantly thinner than that of the wild-type mice, even though there was no difference in the total thickness of the retinas in the two groups of mice [3].
  • Seven cd81(-/-) mice and 11 wildtype (cd81(+/+)) littermates were anesthetized and perfused with paraformaldehyde [3].


  1. Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. Yatsuki, H., Watanabe, H., Hattori, M., Joh, K., Soejima, H., Komoda, H., Xin, Z., Zhu, X., Higashimoto, K., Nishimura, M., Kuratomi, S., Sasaki, H., Sakaki, Y., Mukai, T. DNA Res. (2000) [Pubmed]
  2. Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family. Enklaar, T., Esswein, M., Oswald, M., Hilbert, K., Winterpacht, A., Higgins, M., Zabel, B., Prawitt, D. Genomics (2000) [Pubmed]
  3. Increased density of retinal pigment epithelium in cd81-/- mice. Song, B.K., Levy, S., Geisert, E.E. J. Cell. Biochem. (2004) [Pubmed]
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