Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CDKL3 - cyclin-dependent kinase-like 3

Homo sapiens

Synonyms: Cyclin-dependent kinase-like 3, NKIAMRE, Serine/threonine-protein kinase NKIAMRE

Yee, K.W. et al., Haq, R. et al., Midmer, M. et al.

Yee, Moore, Midmer, Zanke, Tong, Hedley, Minden,

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High impact information on CDKL3

NKIAMRE was deleted at both alleles in 9 of 18 leukemic samples with chromosome band 5q31 abnormalities studied by fluorescence in situ chromosomal hybridization [1].
Sequence similarity to the putative human tumor suppressor gene NKIAMRE, which is lost in leukemic patients with chromosome 5q deletions, suggests that NKIATRE may have a role in restricting cell growth or maintaining differentiation [2].
We report the cloning of the NKIAMRE gene located on human chromosome 5q31 [3].
Human NKIAMRE has significant amino acid identity to related kinases in rat, mouse, Caenorhabditis elegans, and Drosophila, and is widely expressed in human tissues and cell lines [3].

Analytical, diagnostic and therapeutic context of CDKL3

Confocal microscopy demonstrates that NKIAMRE localizes to the cytoplasm [3].

References

Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion. Midmer, M., Haq, R., Squire, J.A., Zanke, B.W. Cancer Res. (1999) [Pubmed]
NKIATRE is a novel conserved cdc2-related kinase. Haq, R., Randall, S., Midmer, M., Yee, K., Zanke, B. Genomics (2001) [Pubmed]
NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. Yee, K.W., Moore, S.J., Midmer, M., Zanke, B.W., Tong, F., Hedley, D., Minden, M.D. Biochem. Biophys. Res. Commun. (2003) [Pubmed]

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