Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MEX3C - mex-3 RNA binding family member C

Homo sapiens

Synonyms: BM-013, FLJ38871, MEX-3C, RING finger and KH domain-containing protein 2, RING finger protein 194, ...

Guzm??n, B. et al.

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Disease relevance of RKHD2

Implication of Chromosome 18 in Hypertension by Sibling Pair and Association Analyses: Putative Involvement of the RKHD2 Gene [1].

High impact information on RKHD2

Our data confirm the implication of chromosome 18 in EH and support a contribution of RKHD2 to the genetic susceptibility of this complex phenotype [1].
We selected 2 RKHD2-tagged single nucleotide polymorphisms, rs1941958 and rs1893379, covering, in terms of linkage disequilibrium, the entire gene, and observed a significant overrepresentation of the rs1941958G-rs1893379T RKHD2 haplotype in the group of hypertensive patients in comparison with controls (2P=0.0004; odds ratio: 2.32) [1].
We also detected epistatic effects between the 2 RKHD2 single nucleotide polymorphisms (2P=0.002; odds ratio: 2.48) [1].
We further focused on the Ring finger and KH domain containing 2 (RKHD2) gene located 6 Kb distal from D18S474 and performed a case-control association study based on linkage disequilibrium in 112 hypertensive patients and 156 control subjects [1].

References

Implication of Chromosome 18 in Hypertension by Sibling Pair and Association Analyses: Putative Involvement of the RKHD2 Gene. Guzm??n, B., Cormand, B., Ribas??s, M., Gonz??lez-N????ez, D., Botey, A., Poch, E. Hypertension (2006) [Pubmed]

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