Disease relevance of RING1

• Also, RING1 colocalizes with these vertebrate PcG proteins in nuclear domains of SW480 human colorectal adenocarcinoma and Saos-2 human osteosarcoma cells [1].
• RING1 was lost in a group of renal-cell carcinomas and testicular germ-cell tumors [2].
• Human Ring-Finger homologous to Inhibitor of apoptosis protein type (hRFI) is a newly discovered gene that has been shown to inhibit death receptor-mediated apoptosis in colorectal cancer cells [3].
• Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif [4].
• RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer [5].

Psychiatry related information on RING1

• A risk behavior profile of the First Ring suburbs surrounding a large Midwestern city is presented and compared to the frequency of these behaviors in a national sample [6].
• Clinical problem-solving. Ring around the diagnosis [7].

High impact information on RING1

• Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K(+) Channels [8].
• Some quantitative parameters of the intranuclear metabolism and export to the cytoplasm of Balbiani ring 1 and 2 RNA molecules in salivary gland cells of Chironomus tentans have been determined [9].
• In a genetic screen for cDNAs bypassing replicative senescence of normal human prostate epithelial cells (HPrEC), we identified CBX7, a gene that encodes a Polycomb protein, as shown by sequence homology, its interaction with Ring1 and its localization to nuclear Polycomb bodies [10].
• Developmentally regulated expression of a Balbiani ring 1 gene for a 180-kD secretory polypeptide in Chironomus tentans salivary glands before larval/pupal ecdysis [11].
• We show that A. vinelandii has two clusters of rnf-like genes: rnf1, whose expression is nif-regulated, and rnf2, which is expressed independently of the nitrogen source in the medium [12].

Chemical compound and disease context of RING1

• Chbl, a 120-kDa proto-oncogene product, whose gene was first identified as part of a transforming gene of a murine retrovirus and whose expression is predominant in haematopoietic cells, consists of an amino-terminal transforming region, a zinc Ring finger, multiple proline-rich stretches, and several potential phosphotyrosine-containing motifs [13].

Biological context of RING1

• To better understand the role of RING1 in regulating gene expression, we overexpressed the protein in mammalian cells and analyzed differences in gene expression levels [14].
• Further, deregulation of RING1 expression leads to oncogenic transformation by deregulation of the expression levels of certain oncogenes [14].
• Furthermore, RING1 overexpression results in enhanced expression of the proto-oncogenes c-jun and c-fos [14].
• Finally, we show that RING1, like Pc, is able to repress gene activity when targeted to a reporter gene [1].
• The motif was found in the sequence of the human RING1 gene, which is proximal to the major histocompatibility complex region on chromosome six [15].

Anatomical context of RING1

• Investigation of the relationship between E2F6 and RING1 by immunofluorescence and confocal analysis, in HL cell lines and paraffin sections, revealed co-expression of both proteins in the same tumour cells [16].
• Therefore, Bmi-1 plays a crucial role in the control of Th2 cell differentiation in a Ring finger-dependent manner by regulating GATA3 protein stability [17].
• Biochemical studies indicate that Bmi-1 interacts with GATA3 in T cells, which is dependent on the Ring finger of Bmi-1 [17].
• METHODS: Ring segments of rabbit basilar artery were prepared for in vitro measurements of isometric force [18].
• All patients underwent papillary muscle shortening using a pericardium pledget-reinforced Polytetrafluoroethylene suture and annuloplasty with a Carpentier-Edwards Physio Annuloplasty Ring [19].

Associations of RING1 with chemical compounds

• RING finger 1 mutations in Parkin produce altered localization of the protein [20].
• GA inhibited parasite growth by arresting transition from Ring to trophozoite [21].
• We recently studied spin flipping of a 270 MeV vertically polarized deuteron beam stored in the Indiana University Cyclotron Facility Cooler Ring [22].
• Chemical-structural properties of tetracycline antibiotics. 4. Ring A tautomerism involving the protonated amide substituent as observed in the crystal structure of alpha-6-deoxyoxytetracycline hydrohalides [23].
• Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites [24].

Physical interactions of RING1

• A short sequence in the N terminus of hSPRY2 was found to bind directly to the Ring finger domain of c-Cbl [25].

Regulatory relationships of RING1

• Moreover, we found that overexpression of RING1 together with KyoT2 in cells inhibited transactivation of RBP-J by NIC [26].

Other interactions of RING1

• Distinct domains in the RING1 protein are involved in the self-association and in the interaction with BMI1 [14].
• Here, we show that RING1 coimmunoprecipitates with a human Pc homolog, the vertebrate PcG protein BMI1, and HPH1, a human homolog of the PcG protein Polyhomeotic (Ph) [1].
• This interaction is dependent upon the HPC3 C-box but, only partially on the RING finger of RING1 [27].
• These results suggested the formation of a three-molecule complex consisting of RBP-J, KyoT2 and RING1 in cells [26].
• Similar to human, but different from rat and mouse, no class I genes are found in the SACM2L- RING1 interval [28].

Analytical, diagnostic and therapeutic context of RING1

• Two-hybrid assay showed that the LIM domain of KyoT was responsible for interacting with the full-length Ring1 and hPc2 [29].
• Immunohistochemistry shows that material with reactivity towards antibody against the C-terminal domain is present in the nuclei, and specifically enriched in Balbiani ring 1 and 2 [30].
• In situ hybridization localized these sequences to Balbiani ring 1 [31].
• To determine the infectious complications associated with transhepatic biliary drainage devices, an analysis of the records of 38 patients who underwent placement of a pigtail catheter (n = 11), a Ring catheter/feeding tube (n = 13), or a Carey-Coons endoprosthesis (n = 15) was carried out [32].
• PURPOSE: The purpose of this study is to compare reliability indices in conventional (Humphrey) and high-pass resolution (Ring) perimetry in healthy subjects followed prospectively at 6-month intervals [33].

References