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Gene Review

RING1  -  ring finger protein 1

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RING1, Polycomb complex protein RING1, RING finger protein 1, RING1A, RNF1, ...
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Disease relevance of RING1


Psychiatry related information on RING1

  • A risk behavior profile of the First Ring suburbs surrounding a large Midwestern city is presented and compared to the frequency of these behaviors in a national sample [6].
  • Clinical problem-solving. Ring around the diagnosis [7].

High impact information on RING1

  • Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K(+) Channels [8].
  • Some quantitative parameters of the intranuclear metabolism and export to the cytoplasm of Balbiani ring 1 and 2 RNA molecules in salivary gland cells of Chironomus tentans have been determined [9].
  • In a genetic screen for cDNAs bypassing replicative senescence of normal human prostate epithelial cells (HPrEC), we identified CBX7, a gene that encodes a Polycomb protein, as shown by sequence homology, its interaction with Ring1 and its localization to nuclear Polycomb bodies [10].
  • Developmentally regulated expression of a Balbiani ring 1 gene for a 180-kD secretory polypeptide in Chironomus tentans salivary glands before larval/pupal ecdysis [11].
  • We show that A. vinelandii has two clusters of rnf-like genes: rnf1, whose expression is nif-regulated, and rnf2, which is expressed independently of the nitrogen source in the medium [12].

Chemical compound and disease context of RING1


Biological context of RING1


Anatomical context of RING1

  • Investigation of the relationship between E2F6 and RING1 by immunofluorescence and confocal analysis, in HL cell lines and paraffin sections, revealed co-expression of both proteins in the same tumour cells [16].
  • Therefore, Bmi-1 plays a crucial role in the control of Th2 cell differentiation in a Ring finger-dependent manner by regulating GATA3 protein stability [17].
  • Biochemical studies indicate that Bmi-1 interacts with GATA3 in T cells, which is dependent on the Ring finger of Bmi-1 [17].
  • METHODS: Ring segments of rabbit basilar artery were prepared for in vitro measurements of isometric force [18].
  • All patients underwent papillary muscle shortening using a pericardium pledget-reinforced Polytetrafluoroethylene suture and annuloplasty with a Carpentier-Edwards Physio Annuloplasty Ring [19].

Associations of RING1 with chemical compounds

  • RING finger 1 mutations in Parkin produce altered localization of the protein [20].
  • GA inhibited parasite growth by arresting transition from Ring to trophozoite [21].
  • We recently studied spin flipping of a 270 MeV vertically polarized deuteron beam stored in the Indiana University Cyclotron Facility Cooler Ring [22].
  • Chemical-structural properties of tetracycline antibiotics. 4. Ring A tautomerism involving the protonated amide substituent as observed in the crystal structure of alpha-6-deoxyoxytetracycline hydrohalides [23].
  • Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites [24].

Physical interactions of RING1


Regulatory relationships of RING1


Other interactions of RING1

  • Distinct domains in the RING1 protein are involved in the self-association and in the interaction with BMI1 [14].
  • Here, we show that RING1 coimmunoprecipitates with a human Pc homolog, the vertebrate PcG protein BMI1, and HPH1, a human homolog of the PcG protein Polyhomeotic (Ph) [1].
  • This interaction is dependent upon the HPC3 C-box but, only partially on the RING finger of RING1 [27].
  • These results suggested the formation of a three-molecule complex consisting of RBP-J, KyoT2 and RING1 in cells [26].
  • Similar to human, but different from rat and mouse, no class I genes are found in the SACM2L- RING1 interval [28].

Analytical, diagnostic and therapeutic context of RING1

  • Two-hybrid assay showed that the LIM domain of KyoT was responsible for interacting with the full-length Ring1 and hPc2 [29].
  • Immunohistochemistry shows that material with reactivity towards antibody against the C-terminal domain is present in the nuclei, and specifically enriched in Balbiani ring 1 and 2 [30].
  • In situ hybridization localized these sequences to Balbiani ring 1 [31].
  • To determine the infectious complications associated with transhepatic biliary drainage devices, an analysis of the records of 38 patients who underwent placement of a pigtail catheter (n = 11), a Ring catheter/feeding tube (n = 13), or a Carey-Coons endoprosthesis (n = 15) was carried out [32].
  • PURPOSE: The purpose of this study is to compare reliability indices in conventional (Humphrey) and high-pass resolution (Ring) perimetry in healthy subjects followed prospectively at 6-month intervals [33].


  1. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. Satijn, D.P., Gunster, M.J., van der Vlag, J., Hamer, K.M., Schul, W., Alkema, M.J., Saurin, A.J., Freemont, P.S., van Driel, R., Otte, A.P. Mol. Cell. Biol. (1997) [Pubmed]
  2. Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays. Sánchez-Beato, M., Sánchez, E., González-Carreró, J., Morente, M., Díez, A., Sánchez-Verde, L., Martín, M.C., Cigudosa, J.C., Vidal, M., Piris, M.A. Mod. Pathol. (2006) [Pubmed]
  3. Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL. Konishi, T., Sasaki, S., Watanabe, T., Kitayama, J., Nagawa, H. Oncogene (2006) [Pubmed]
  4. Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif. Feng, F., Davis, A., Lake, J.A., Carr, J., Xia, W., Burrell, C., Li, P. J. Virol. (2004) [Pubmed]
  5. RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer. Fang, S., Lorick, K.L., Jensen, J.P., Weissman, A.M. Semin. Cancer Biol. (2003) [Pubmed]
  6. Health risk behaviors in a unique population-first ring suburban adolescents. Larkin, E.M., Frank, J.L., Knight, K.N., Frank, S.H. Journal of community health (2007) [Pubmed]
  7. Clinical problem-solving. Ring around the diagnosis. Bonilla, M.F., Kaul, D.R., Saint, S., Isada, C.M., Brotman, D.J. N. Engl. J. Med. (2006) [Pubmed]
  8. Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K(+) Channels. Ye, S., Li, Y., Chen, L., Jiang, Y. Cell (2006) [Pubmed]
  9. Quantitation of turnover and export to the cytoplasm of hnRNA transcribed in the Balbiani rings. Egyházi, E. Cell (1976) [Pubmed]
  10. Polycomb CBX7 has a unifying role in cellular lifespan. Gil, J., Bernard, D., Martínez, D., Beach, D. Nat. Cell Biol. (2004) [Pubmed]
  11. Developmentally regulated expression of a Balbiani ring 1 gene for a 180-kD secretory polypeptide in Chironomus tentans salivary glands before larval/pupal ecdysis. Dreesen, T.D., Lezzi, M., Case, S.T. J. Cell Biol. (1988) [Pubmed]
  12. Genes required for rapid expression of nitrogenase activity in Azotobacter vinelandii. Curatti, L., Brown, C.S., Ludden, P.W., Rubio, L.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. Cbl: complex formation and functional implications. Liu, Y.C., Altman, A. Cell. Signal. (1998) [Pubmed]
  14. RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity. Satijn, D.P., Otte, A.P. Mol. Cell. Biol. (1999) [Pubmed]
  15. Identification and preliminary characterization of a protein motif related to the zinc finger. Lovering, R., Hanson, I.M., Borden, K.L., Martin, S., O'Reilly, N.J., Evan, G.I., Rahman, D., Pappin, D.J., Trowsdale, J., Freemont, P.S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  16. Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NFkappaB transcription factors. Sánchez-Beato, M., Sánchez, E., García, J.F., Pérez-Rosado, A., Montoya, M.C., Fraga, M., Artiga, M.J., Navarrete, M., Abraira, V., Morente, M., Esteller, M., Koseki, H., Vidal, M., Piris, M.A. J. Pathol. (2004) [Pubmed]
  17. Regulation of Th2 Cell Development by Polycomb Group Gene bmi-1 through the Stabilization of GATA3. Hosokawa, H., Kimura, M.Y., Shinnakasu, R., Suzuki, A., Miki, T., Koseki, H., van Lohuizen, M., Yamashita, M., Nakayama, T. J. Immunol. (2006) [Pubmed]
  18. Platelets augment rabbit cerebral artery constriction by activating protein kinase C. Germann, P., Laher, I., Bevan, J.A. Stroke (1991) [Pubmed]
  19. Papillary muscle shortening for mitral valve reconstruction in patients with ischaemic mitral insufficiency. Fasol, R., Wild, T., Pfannmüller, B., Stumpf, J., Hacker, R. Eur. Heart J. (1998) [Pubmed]
  20. RING finger 1 mutations in Parkin produce altered localization of the protein. Cookson, M.R., Lockhart, P.J., McLendon, C., O'Farrell, C., Schlossmacher, M., Farrer, M.J. Hum. Mol. Genet. (2003) [Pubmed]
  21. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. Banumathy, G., Singh, V., Pavithra, S.R., Tatu, U. J. Biol. Chem. (2003) [Pubmed]
  22. First spin flipping of a stored spin-1 polarized beam. Morozov, V.S., Etienne, Z.B., Kandes, M.C., Krisch, A.D., Leonova, M.A., Sivers, D.W., Wong, V.K., Yonehara, K., Anferov, V.A., Meyer, H.O., Schwandt, P., Stephenson, E.J., von Przewoski, B. Phys. Rev. Lett. (2003) [Pubmed]
  23. Chemical-structural properties of tetracycline antibiotics. 4. Ring A tautomerism involving the protonated amide substituent as observed in the crystal structure of alpha-6-deoxyoxytetracycline hydrohalides. Stezowski, J.J. J. Am. Chem. Soc. (1977) [Pubmed]
  24. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Elly, C., Witte, S., Zhang, Z., Rosnet, O., Lipkowitz, S., Altman, A., Liu, Y.C. Oncogene (1999) [Pubmed]
  25. Evidence for direct interaction between Sprouty and Cbl. Wong, E.S., Lim, J., Low, B.C., Chen, Q., Guy, G.R. J. Biol. Chem. (2001) [Pubmed]
  26. RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2. Qin, H., Wang, J., Liang, Y., Taniguchi, Y., Tanigaki, K., Han, H. Nucleic Acids Res. (2004) [Pubmed]
  27. HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. Bárdos, J.I., Saurin, A.J., Tissot, C., Duprez, E., Freemont, P.S. J. Biol. Chem. (2000) [Pubmed]
  28. Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region. Sudbrak, R., Reinhardt, R., Hennig, S., Lehrach, H., Günther, E., Walter, L. Immunogenetics (2003) [Pubmed]
  29. The interactions of LIM protein KyoT with polycomb proteins. Li, R., Zhang, R. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (2003) [Pubmed]
  30. Nuclear localization of a DNA-binding C-terminal domain from Balbiani ring coded secretory protein. Botella, L., Grond, C., Saiga, H., Edström, J.E. EMBO J. (1988) [Pubmed]
  31. A second gene in a Balbiani ring. Chironomus salivary glands contain a 6.5-kb poly(A)+ RNA that is transcribed from a hierarchy of tandem repeated sequences in Balbiani ring 1. Dreesen, T.D., Bower, J.R., Case, S.T. J. Biol. Chem. (1985) [Pubmed]
  32. Infections associated with transhepatic biliary drainage devices. Szabo, S., Mendelson, M.H., Mitty, H.A., Bruckner, H.W., Hirschman, S.Z. Am. J. Med. (1987) [Pubmed]
  33. Comparison of reliability indices in conventional and high-pass resolution perimetry. Chauhan, B.C., Mohandas, R.N., Whelan, J.H., McCormick, T.A. Ophthalmology (1993) [Pubmed]
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