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Gene Review:

TRIAP1 - TP53 regulated inhibitor of apoptosis 1

Homo sapiens

Synonyms: 15E1.1, HSPC132, MDM35, P53CSV, Protein 15E1.1, ...

Wang, Y. et al., Zareba, S. et al., Hayashi, T. et al., Pérez-Bendito, D. et al., Park, W.R. et al.

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Disease relevance of TRIAP1

Female NZB/WF1 mice produce high titers of antinuclear antibodies and invariably succumb to severe glomerulonephritis by 12 months of age [1].
Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5 [1].

High impact information on TRIAP1

p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway [2].
The variation of fluorescence intensity during the reaction between uric acid and 1,1,3-tricyano-2-amino-1-propene (triap) in the presence of hydrogen peroxide is monitored [3].
The present study has examined relationship between cutaneous microvessel injury and adhesion molecule expression on the endothelium by cytokines in NZBxNZWF1 (B/WF1) mice, a model for human systemic lupus erythematosus [4].
Azodyes, derivatives of 1,2,4-triazole and pyrocatechine: 3-(3',4'-dihydroxyphenylazo-1')-1,2,4-triazole (TRIAP) and 3-(3',4'-dihydroxyphenylazo-1')-5-mercapto-1,2,4-triazole (METRIAP), were used for spectrophotometric determination of Al. in composite pharmaceutical preparations [5].

References

Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Wang, Y., Hu, Q., Madri, J.A., Rollins, S.A., Chodera, A., Matis, L.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. Park, W.R., Nakamura, Y. Cancer Res. (2005) [Pubmed]
Nonenzymatic stopped-flow fluorimetric method for direct determination of uric acid in serum and urine. Pérez-Bendito, D., Gómez-Hens, A., Gutiérrez, M.C., Antón, S. Clin. Chem. (1989) [Pubmed]
ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice. Hayashi, T., Hasegawa, K., Ichinohe, N. Histol. Histopathol. (2005) [Pubmed]
Spectrophotometric determination of aluminium in pharmaceutical preparations by azo dyes of 1,2,4-triazole series. Zareba, S., Melke, J. Pharmaceutica acta Helvetiae. (2000) [Pubmed]

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TRIAP1	Bos taurus
TRIAP1	Canis lupus familiaris
triap1	Danio rerio
TRIAP1	Gallus gallus
Triap1	Mus musculus
TRIAP1	Pan troglodytes
Triap1	Rattus norvegicus
LOC100910137	Rattus norvegicus
triap1	Xenopus (Silurana) tropicalis

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