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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CHMP5  -  charged multivesicular body protein 5

Homo sapiens

Synonyms: C9orf83, CGI-34, Charged multivesicular body protein 5, Chromatin-modifying protein 5, HSPC177, ...
 
 
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Disease relevance of CHMP5

  • Surprisingly, CHMP5 depletion results in an increase in the release of infectious HIV-1 particles [1].
  • Comparison of overexpression and siRNA phenotypes suggests that the roles of these proteins in MVB formation may be more specifically addressed using RNA interference and that both LIP5 and CHMP5 function in MVB sorting, whereas only LIP5 is required for HIV release [1].
 

High impact information on CHMP5

  • Depletion of CHMP5 by siRNA does not affect the distribution or morphology of early endosomes, lysosomes, or Golgi but does result in reduced degradation of the EGFR similar to silencing of LIP5 [1].
  • Inhibition of protein synthesis caused a consistent reduction in the transcription of p53 and PNAS-2 [2].

References

  1. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. Ward, D.M., Vaughn, M.B., Shiflett, S.L., White, P.L., Pollock, A.L., Hill, J., Schnegelberger, R., Sundquist, W.I., Kaplan, J. J. Biol. Chem. (2005) [Pubmed]
  2. Sensitive genetic biomarkers for determining apoptosis in the brown bullhead (Ameiurus nebulosus). Busch, C.R., Heath, D.D., Hubberstey, A. Gene (2004) [Pubmed]
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