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Gene Review

PEX5L  -  peroxisomal biogenesis factor 5-like

Homo sapiens

Synonyms: PEX2-related protein, PEX5-like protein, PEX5-related protein, PEX5R, PEX5RP, ...
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High impact information on PEX5L

  • To investigate this possibility, we characterized PEX5 expression and found that it undergoes alternative splicing, producing two transcripts, one containing (PEX5L) and one lacking (PEX5S) a 111 bp internal exon [1].
  • Furthermore, transfection of PBD005 cells with PEX5L cDNAs containing the patient mutations (which are located downstream of the additional exon) restores PTS2 but not PTS1 import [1].
  • Human cells generate two isoforms of PEX5 through alternative splicing, PEX5S and PEX5L, and PEX5L contains an additional insert 37 amino acids long [2].
  • In this report we map the regions of human PEX5L involved in PTS2 protein import, PEX7 interaction, and targeting to peroxisomes [2].
  • A mutation in PEX5 that changes a conserved serine of this motif abrogates PTS2 protein import in mammalian cells and reduces the interaction of PEX5L and PEX7 in vitro [2].

Biological context of PEX5L


Other interactions of PEX5L


  1. An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes. Braverman, N., Dodt, G., Gould, S.J., Valle, D. Hum. Mol. Genet. (1998) [Pubmed]
  2. Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p. Dodt, G., Warren, D., Becker, E., Rehling, P., Gould, S.J. J. Biol. Chem. (2001) [Pubmed]
  3. Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals. Amery, L., Sano, H., Mannaerts, G.P., Snider, J., Van Looy, J., Fransen, M., Van Veldhoven, P.P. Biochem. J. (2001) [Pubmed]
  4. Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14. Schliebs, W., Saidowsky, J., Agianian, B., Dodt, G., Herberg, F.W., Kunau, W.H. J. Biol. Chem. (1999) [Pubmed]
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