Gene Review:
PEX5 - peroxisomal biogenesis factor 5
Homo sapiens
Synonyms:
PBD2A, PBD2B, PTS1 receptor, PTS1-BP, PTS1R, ...
- Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice. Janssen, A., Baes, M., Gressens, P., Mannaerts, G.P., Declercq, P., Van Veldhoven, P.P. Lab. Invest. (2000)
- Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders. Wiemer, E.A., Nuttley, W.M., Bertolaet, B.L., Li, X., Francke, U., Wheelock, M.J., Anné, U.K., Johnson, K.R., Subramani, S. J. Cell Biol. (1995)
- Lack of association of the pregnane X receptor (PXR/NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis. Ho, G.T., Soranzo, N., Tate, S.K., Drummond, H., Nimmo, E.R., Tenesa, A., Arnott, I.D., Satsangi, J. Gut (2006)
- In silico prediction of pregnane x receptor activators by machine learning approache. Ung, C.Y., Li, H., Yap, C.W., Chen, Y.Z. Mol. Pharmacol. (2007)
- Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Xue, Y., Chao, E., Zuercher, W.J., Willson, T.M., Collins, J.L., Redinbo, M.R. Bioorg. Med. Chem. (2007)
- The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Dammai, V., Subramani, S. Cell (2001)
- Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Dodt, G., Braverman, N., Wong, C., Moser, A., Moser, H.W., Watkins, P., Valle, D., Gould, S.J. Nat. Genet. (1995)
- Convergence of model systems for peroxisome biogenesis. Subramani, S. Curr. Opin. Cell Biol. (1996)
- Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor. Dodt, G., Gould, S.J. J. Cell Biol. (1996)
- Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14. Schliebs, W., Saidowsky, J., Agianian, B., Dodt, G., Herberg, F.W., Kunau, W.H. J. Biol. Chem. (1999)
- PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12. Harper, C.C., Berg, J.M., Gould, S.J. J. Biol. Chem. (2003)
- Isolation of a new peroxisome-deficient CHO cell mutant defective in peroxisome targeting signal-1 receptor. Tsukamoto, T., Bogaki, A., Okumoto, K., Tateishi, K., Fujiki, Y., Shimozawa, N., Suzuki, Y., Kondo, N., Osumi, T. Biochem. Biophys. Res. Commun. (1997)
- Peroxin 5-peroxin 14 association in the protozoan Leishmania donovani involves a novel protein-protein interaction motif. Madrid, K.P., Jardim, A. Biochem. J. (2005)
- Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export. Miyata, N., Fujiki, Y. Mol. Cell. Biol. (2005)
- Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import. Otera, H., Setoguchi, K., Hamasaki, M., Kumashiro, T., Shimizu, N., Fujiki, Y. Mol. Cell. Biol. (2002)
- Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein. Costa-Rodrigues, J., Carvalho, A.F., Fransen, M., Hambruch, E., Schliebs, W., Sá-Miranda, C., Azevedo, J.E. J. Biol. Chem. (2005)
- Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. Hogenboom, S., Romeijn, G.J., Houten, S.M., Baes, M., Wanders, R.J., Waterham, H.R. J. Lipid Res. (2002)
- Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Gong, H., Singh, S.V., Singh, S.P., Mu, Y., Lee, J.H., Saini, S.P., Toma, D., Ren, S., Kagan, V.E., Day, B.W., Zimniak, P., Xie, W. Mol. Endocrinol. (2006)
- Pex5p binding affinities for canonical and noncanonical PTS1 peptides. Maynard, E.L., Gatto, G.J., Berg, J.M. Proteins (2004)
- Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p. Okumoto, K., Abe, I., Fujiki, Y. J. Biol. Chem. (2000)
- Clinical, biochemical and genetic aspects and neuronal migration in peroxisome biogenesis disorders. Suzuki, Y., Shimozawa, N., Imamura, A., Fukuda, S., Zhang, Z., Orii, T., Kondo, N. J. Inherit. Metab. Dis. (2001)
- Molecular Mechanisms of Import of Peroxisome-targeting Signal Type 2 (PTS2) Proteins by PTS2 Receptor Pex7p and PTS1 Receptor Pex5pL. Mukai, S., Fujiki, Y. J. Biol. Chem. (2006)
- Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1. Harano, T., Nose, S., Uezu, R., Shimizu, N., Fujiki, Y. Biochem. J. (2001)
- Peroxisome targeting of porcine 17beta-hydroxysteroid dehydrogenase type IV/D-specific multifunctional protein 2 is mediated by its C-terminal tripeptide AKI. Möller, G., Lüders, J., Markus, M., Husen, B., Van Veldhoven, P.P., Adamski, J. J. Cell. Biochem. (1999)
- Disruption of the interaction of the longer isoform of Pex5p, Pex5pL, with Pex7p abolishes peroxisome targeting signal type 2 protein import in mammals. Study with a novel Pex5-impaired Chinese hamster ovary cell mutant. Matsumura, T., Otera, H., Fujiki, Y. J. Biol. Chem. (2000)
- Temperature-sensitive phenotype of Chinese hamster ovary cells defective in PEX5 gene. Ito, R., Huang, Y., Yao, C., Shimozawa, N., Suzuki, Y., Kondo, N., Imanaka, T., Usuda, N., Ito, M. Biochem. Biophys. Res. Commun. (2001)
- Formation of peroxisomes from peroxisomal ghosts in a peroxisome-deficient mammalian cell mutant upon complementation by protein microinjection. Yamasaki, M., Hashiguchi, N., Fujiwara, C., Imanaka, T., Tsukamoto, T., Osumi, T. J. Biol. Chem. (1999)