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Gene Review

SMAD2  -  SMAD family member 2

Bos taurus

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High impact information on SMAD2


Other interactions of SMAD2

  • The ECM production stimulation by TGF-beta or CA TbetaR-I was accelerated by the overexpression of Smad2, Smad3, and/or Smad4 and inhibited by that of Smad7 [2].


  1. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. Brown, J.D., DiChiara, M.R., Anderson, K.R., Gimbrone, M.A., Topper, J.N. J. Biol. Chem. (1999) [Pubmed]
  2. Extracellular matrix production regulation by TGF-beta in corneal endothelial cells. Usui, T., Takase, M., Kaji, Y., Suzuki, K., Ishida, K., Tsuru, T., Miyata, K., Kawabata, M., Yamashita, H. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
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