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Gene Review

MPP6  -  membrane protein, palmitoylated 6 (MAGUK...

Homo sapiens

Synonyms: MAGUK p55 subfamily member 6, PALS2, VAM-1, VAM1, Veli-associated MAGUK 1, ...
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High impact information on MPP6

  • Pals2 was found to exist in two splice forms of 539 and 553 amino acids and maps to mouse chromosome 6 [1].
  • Our results therefore suggest that VAM-1 may function by promoting the assembly of a Veli-1 containing protein complex in neuronal as well as epithelial cells [2].
  • VAM-1 mRNA was abundant in human testis, brain, and kidney with lower levels detectable in other tissues [2].
  • The complete cDNA sequence of VAM-1, tissue distribution of its mRNA, genomic structure, chromosomal localization, and Veli-1 binding properties are presented [2].

Other interactions of MPP6

  • VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain [2].

Analytical, diagnostic and therapeutic context of MPP6

  • Here, we demonstrate that M-phase phosphoprotein 6 (MPP6), a protein reported previously to co-purify with the TAP-tagged human exosome, accumulates in the nucleoli of HEp-2 cells and associates with a subset of nuclear exosomes as evidenced by co-immunoprecipitation and biochemical fractionation experiments [3].


  1. Molecular cloning and characterization of Pals, proteins associated with mLin-7. Kamberov, E., Makarova, O., Roh, M., Liu, A., Karnak, D., Straight, S., Margolis, B. J. Biol. Chem. (2000) [Pubmed]
  2. VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. Tseng, T.C., Marfatia, S.M., Bryant, P.J., Pack, S., Zhuang, Z., O'Brien, J.E., Lin, L., Hanada, T., Chishti, A.H. Biochim. Biophys. Acta (2001) [Pubmed]
  3. MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. Schilders, G., Raijmakers, R., Raats, J.M., Pruijn, G.J. Nucleic Acids Res. (2005) [Pubmed]
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