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Gene Review

PFKFB2  -  6-phosphofructo-2-kinase/fructose-2,6...

Homo sapiens

Synonyms: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, 6PF-2-K/Fru-2,6-P2ase 2, 6PF-2-K/Fru-2,6-P2ase heart-type isozyme, PFK/FBPase 2
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Disease relevance of PFKFB2

  • Further studies showed that PFKFB-1 and PFKFB-2 were highly responsive to hypoxia mimics such as transition metals, iron chelators and inhibitors of HIF hydroxylases, suggesting that the hypoxia responsiveness of these genes is also regulated by HIF proteins [1].

High impact information on PFKFB2

  • Our analysis argued against most of the model-based hypotheses and instead identified a small number of novel candidate genes, including PFKFB2, a key regulator of glucose metabolism; ZBTB16, a putative transcription factor; and SNF1LK, a protein kinase implicated in cell-cycle regulation [2].
  • PFKFB2, which encodes the heart isozyme of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, was assigned to chromosome 13 in the rat and to chromosome 1 in the human by hybridization of DNA from somatic cell hybrids [3].
  • The genomic sequence of the PFKFB2 gene spans 22,485 bp and contains 15 exons [4].
  • In the present study, we report the characterization of the PFK-2/FBPase-2 heart isoform gene in humans (PFKFB2), including a full analysis of repetitive sequences and potential transcription binding sites [4].
  • Comparison of the human PFKFB2 gene to the homologous genes in rat and ox outlines a significant conservation of the intron-exon structure, sequence of 5' and 3' flanking regions, and simple sequence repetitive element positions [4].


  1. Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo. Minchenko, O., Opentanova, I., Caro, J. FEBS Lett. (2003) [Pubmed]
  2. Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia. Schmidt, S., Rainer, J., Riml, S., Ploner, C., Jesacher, S., Achmüller, C., Presul, E., Skvortsov, S., Crazzolara, R., Fiegl, M., Raivio, T., Jänne, O.A., Geley, S., Meister, B., Kofler, R. Blood (2006) [Pubmed]
  3. Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. Hilliker, C.E., Darville, M.I., Aly, M.S., Chikri, M., Szpirer, C., Marynen, P., Rousseau, G.G., Cassiman, J.J. Genomics (1991) [Pubmed]
  4. Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). Heine-Suñer, D., Díaz-Guillén, M.A., Lange, A.J., Rodríguez de Córdoba, S. Eur. J. Biochem. (1998) [Pubmed]
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