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Gene Review

ATP6V1A  -  ATPase, H+ transporting, lysosomal 70kDa,...

Homo sapiens

Synonyms: ATP6A1, ATP6V1A1, HO68, V-ATPase 69 kDa subunit, V-ATPase subunit A, ...
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High impact information on ATP6V1A

  • Screening of a cDNA library made from human osteoclastoma tumor tissue revealed the presence of two isoforms of subunit A. HO68 is a cDNA of 3.1 kilobase pairs, corresponding to a mRNA of approximately 3.4 kilobases in osteoclastoma only, encoding a protein of 615 amino acids with a predicted molecular mass of 68177 Da [1].
  • HO68 shows the closest sequence homology (95% at the amino acid level) to subunit A of a proton-secreting vacuolar-type H(+)-ATPase located in the apical membrane of midgut goblet cells of tobacco hornworm larva (Manduca sexta) [1].
  • These clones share homology with previously published subunit A sequences, and this, together with the tissue distribution of the mRNA, suggests there are ubiquitous (VA68-type) and tissue-specific (HO68-type) isoforms [1].
  • We propose that HO68 could correspond to an isoform of subunit A specific for a vacuolar-type H(+)-ATPase located in the osteoclast plasma membrane [1].
  • These findings suggest that the subunit A highly expressed in human osteoclasts is the ubiquitous isoform, VA68 [2].


  1. Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma. van Hille, B., Richener, H., Evans, D.B., Green, J.R., Bilbe, G. J. Biol. Chem. (1993) [Pubmed]
  2. The ubiquitous VA68 isoform of subunit A of the vacuolar H(+)-ATPase is highly expressed in human osteoclasts. van Hille, B., Richener, H., Green, J.R., Bilbe, G. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
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