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Gene Review:

Vha68-1 - Vacuolar H[+] ATPase 68kD subunit 1

Drosophila melanogaster

Synonyms: A subunit, ATP6V1A, CG12403, Dmel\CG12403, V-ATPase 69 kDa subunit 1, ...

Finbow, M.E. et al., Dow, J.A. et al., Mousset, S. et al.

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High impact information on Vha68-1

Taken together, the data suggest that in Drosophila and Manduca, the same polypeptide is both the proteolipid subunit c component of the V-ATPase and the ductin component of gap junctions [1].
Four loci [Acp26Aa, Fbp2, Vha68-1, and Su(H)] were previously found to deviate from a neutral mutation-drift equilibrium as a consequence of one or several selective sweeps [2].
A cDNA library from Manduca sexta larval midguts and Malpighian tubules was screened with a Drosophila melanogaster cDNA encoding the 16-kDa proteolipid subunit of the V-ATPase, and a 1.4-kb cDNA sequenced in its entirety [3].

Anatomical context of Vha68-1

The 16 kDa proteolipid (subunit c) of the eukaryotic vacuolar H(+)-ATPase (V-ATPase) is closely related to the ductin polypeptide that forms the connexon channel of gap junctions in the crustacean Nephrops norvegicus [1].

References

Evidence that the 16 kDa proteolipid (subunit c) of the vacuolar H(+)-ATPase and ductin from gap junctions are the same polypeptide in Drosophila and Manduca: molecular cloning of the Vha16k gene from Drosophila. Finbow, M.E., Goodwin, S.F., Meagher, L., Lane, N.J., Keen, J., Findlay, J.B., Kaiser, K. J. Cell. Sci. (1994) [Pubmed]
Evidence of a high rate of selective sweeps in African Drosophila melanogaster. Mousset, S., Brazier, L., Cariou, M.L., Chartois, F., Depaulis, F., Veuille, M. Genetics (2003) [Pubmed]
Analysis of the gene encoding a 16-kDa proteolipid subunit of the vacuolar H(+)-ATPase from Manduca sexta midgut and tubules. Dow, J.A., Goodwin, S.F., Kaiser, K. Gene (1992) [Pubmed]

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VHA-A	Arabidopsis thaliana
ATP6V1A	Bos taurus
vha-13	Caenorhabditis elegans
ATP6V1A	Canis lupus familiaris
atp6v1aa	Danio rerio
atp6v1ab	Danio rerio
ATP6V1A	Gallus gallus
ATP6V1A	Homo sapiens
KLLA0F05401g	Kluyveromyces lactis NRRL Y-1140
LOC696878	Macaca mulatta
ATP6V1A	Macaca mulatta
MGG_08087	Magnaporthe oryzae 70-15
Atp6v1a	Mus musculus
NCU01207	Neurospora crassa OR74A
Os02g0175400	Oryza sativa Japonica Group
Os06g0662000	Oryza sativa Japonica Group
ATP6V1A	Pan troglodytes
Atp6v1a	Rattus norvegicus
VMA1	Saccharomyces cerevisiae S288c
vma1	Schizosaccharomyces pombe 972h-
atp6v1a	Xenopus (Silurana) tropicalis

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