High impact information on PIN1L

• As part of this study, we isolated the putative polar auxin transport genes, PttLAX1-PttLAX3 and PttPIN1-PttPIN3, belonging to the AUX1-like family of influx and PIN1-like efflux carriers, respectively [1].
• Primers were designed to discriminate between the two transcripts, and PCR on DNA from hamster/human somatic cell hybrids retaining chromosomes 1 or 19 was used to map the human PIN1 gene to chromosome 19, and PIN1L, a closely related gene, to chromosome 1 [2].
• The protein encoded by PIN1L may have some functional role or alternatively PIN1L may be a transcribed pseudogene [2].

Biological context of PIN1L

• The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31 [2].
• The PIN1L cDNA is 89% identical at the nucleotide level to the PIN1 transcript, but contains a shift in the reading frame [2].

Analytical, diagnostic and therapeutic context of PIN1L

• PCR was used to clone the coding region for PIN1L [2].

References