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Gene Review

Spt5  -  CG7626 gene product from transcript CG7626-RA

Drosophila melanogaster

Synonyms: CG7626, DRB sensitivity-inducing factor large subunit, DSIF, DSIF large subunit, Dmel\CG7626, ...
 
 
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High impact information on Spt5

  • In vivo protein-DNA cross-linking showed that NELF and DSIF associate with the promoter region before heat shock [1].
  • High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation [2].
  • W049 alters the C-terminal domain of Spt5 and affects its activity in vitro, impairing its abilities to confer sensitivity to the transcriptional inhibitor DRB and to stimulate transcription at limiting nucleotide concentrations [3].
  • Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila [3].
 

Biological context of Spt5

  • Here, we show that Drosophila Spt5 and Spt6 colocalize at a large number of transcriptionally active chromosomal sites on polytene chromosomes and are rapidly recruited to endogenous and transgenic heat shock loci upon heat shock [2].

References

  1. NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Wu, C.H., Yamaguchi, Y., Benjamin, L.R., Horvat-Gordon, M., Washinsky, J., Enerly, E., Larsson, J., Lambertsson, A., Handa, H., Gilmour, D. Genes Dev. (2003) [Pubmed]
  2. High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation. Andrulis, E.D., Guzmán, E., Döring, P., Werner, J., Lis, J.T. Genes Dev. (2000) [Pubmed]
  3. Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. Jennings, B.H., Shah, S., Yamaguchi, Y., Seki, M., Phillips, R.G., Handa, H., Ish-Horowicz, D. Curr. Biol. (2004) [Pubmed]
 
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