High impact information on supt5h

• The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo [1].
• However, the requirement for spt 5 for cell viability in a metazoan organism has not been addressed [2].
• This finding indicates that spt 5-dependent transcript elongation is required cell-autonomously for a complex cell migration but not for the survival of these same cells [2].
• We determined that zebrafish foggy/spt 5 is required cell-autonomously for the posterior migration of facial branchiomotor neurons from rhombomere 4 (r4) into r6 and r7 of the hindbrain [2].

Biological context of supt5h

• Altogether, our results suggest that Spt6 and Spt5 play essential roles of comparable importance for promoting transcription during embryogenesis [1].
• Through real-time RT-PCR analysis, we demonstrate that Spt6 and Spt5 are both required for efficient kinetics of hsp70 transcription in vivo [1].

References