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Gene Review

supt5h  -  suppressor of Ty 5 homolog (S. cerevisiae)

Danio rerio

Synonyms: DRB sensitivity-inducing factor large subunit, DSIF large subunit, Protein foggy, SO:0000704, Spt5, ...
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High impact information on supt5h

  • The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo [1].
  • However, the requirement for spt 5 for cell viability in a metazoan organism has not been addressed [2].
  • This finding indicates that spt 5-dependent transcript elongation is required cell-autonomously for a complex cell migration but not for the survival of these same cells [2].
  • We determined that zebrafish foggy/spt 5 is required cell-autonomously for the posterior migration of facial branchiomotor neurons from rhombomere 4 (r4) into r6 and r7 of the hindbrain [2].

Biological context of supt5h

  • Altogether, our results suggest that Spt6 and Spt5 play essential roles of comparable importance for promoting transcription during embryogenesis [1].
  • Through real-time RT-PCR analysis, we demonstrate that Spt6 and Spt5 are both required for efficient kinetics of hsp70 transcription in vivo [1].


  1. The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Keegan, B.R., Feldman, J.L., Lee, D.H., Koos, D.S., Ho, R.K., Stainier, D.Y., Yelon, D. Development (2002) [Pubmed]
  2. Zebrafish foggy/spt 5 is required for migration of facial branchiomotor neurons but not for their survival. Cooper, K.L., Armstrong, J., Moens, C.B. Dev. Dyn. (2005) [Pubmed]
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