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Gene Review

PFN2  -  profilin 2

Bos taurus

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High impact information on LOC539034


Associations of LOC539034 with chemical compounds


Physical interactions of LOC539034


Other interactions of LOC539034

  • We show further that PIP2 effectively competes for binding of profilin I to poly-L-proline, since this isoform, but not profilin II, can be eluted from a poly-L-proline column with PIP2 [1].

Analytical, diagnostic and therapeutic context of LOC539034


  1. The mammalian profilin isoforms display complementary affinities for PIP2 and proline-rich sequences. Lambrechts, A., Verschelde, J.L., Jonckheere, V., Goethals, M., Vandekerckhove, J., Ampe, C. EMBO J. (1997) [Pubmed]
  2. Dimerization of profilin II upon binding the (GP5)3 peptide from VASP overcomes the inhibition of actin nucleation by profilin II and thymosin beta4. Jonckheere, V., Lambrechts, A., Vandekerckhove, J., Ampe, C. FEBS Lett. (1999) [Pubmed]
  3. Purification and characterization of bovine profilin II. Actin, poly(L-proline) and inositolphospholipid binding. Lambrechts, A., van Damme, J., Goethals, M., Vandekerckhove, J., Ampe, C. Eur. J. Biochem. (1995) [Pubmed]
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