Chemical Compound Review:
proline pyrrolidine-2-carboxylic acid
Synonyms:
CCCu, Hpro, DL-Proline, Poly-L-proline, H-DL-Pro-OH, ...
- A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. Moreau, V., Frischknecht, F., Reckmann, I., Vincentelli, R., Rabut, G., Stewart, D., Way, M. Nat. Cell Biol. (2000)
- Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase. Myllyharju, J., Kivirikko, K.I. EMBO J. (1999)
- Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility. Southwick, F.S., Purich, D.L. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Genome-wide analysis of p53 under hypoxic conditions. Hammond, E.M., Mandell, D.J., Salim, A., Krieg, A.J., Johnson, T.M., Shirazi, H.A., Attardi, L.D., Giaccia, A.J. Mol. Cell. Biol. (2006)
- A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems. Giesemann, T., Rathke-Hartlieb, S., Rothkegel, M., Bartsch, J.W., Buchmeier, S., Jockusch, B.M., Jockusch, H. J. Biol. Chem. (1999)
- Interactions between immunogenic peptides and MHC proteins. Rothbard, J.B., Gefter, M.L. Annu. Rev. Immunol. (1991)
- Competitor analogs for defined T cell antigens: peptides incorporating a putative binding motif and polyproline or polyglycine spacers. Maryanski, J.L., Verdini, A.S., Weber, P.C., Salemme, F.R., Corradin, G. Cell (1990)
- Crystal and molecular structure of a collagen-like peptide at 1.9 A resolution. Bella, J., Eaton, M., Brodsky, B., Berman, H.M. Science (1994)
- Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Shutter, J.R., Graham, M., Kinsey, A.C., Scully, S., Lüthy, R., Stark, K.L. Genes Dev. (1997)
- Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Shi, Y., Alin, K., Goff, S.P. Genes Dev. (1995)
- KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. Lee, J.H., Miele, M.E., Hicks, D.J., Phillips, K.K., Trent, J.M., Weissman, B.E., Welch, D.R. J. Natl. Cancer Inst. (1996)
- Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Beneken, J., Tu, J.C., Xiao, B., Nuriya, M., Yuan, J.P., Worley, P.F., Leahy, D.J. Neuron (2000)
- Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. Wang, X., Kibschull, M., Laue, M.M., Lichte, B., Petrasch-Parwez, E., Kilimann, M.W. J. Cell Biol. (1999)
- Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells. Haarer, B.K., Lillie, S.H., Adams, A.E., Magdolen, V., Bandlow, W., Brown, S.S. J. Cell Biol. (1990)
- Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A. Huber, A.H., Wang, Y.M., Bieber, A.J., Bjorkman, P.J. Neuron (1994)
- In vivo importance of actin nucleotide exchange catalyzed by profilin. Wolven, A.K., Belmont, L.D., Mahoney, N.M., Almo, S.C., Drubin, D.G. J. Cell Biol. (2000)
- The epidermal growth factor receptor juxtamembrane domain has multiple basolateral plasma membrane localization determinants, including a dominant signal with a polyproline core. He, C., Hobert, M., Friend, L., Carlin, C. J. Biol. Chem. (2002)
- Microinjected profilin affects cytoplasmic streaming in plant cells by rapidly depolymerizing actin microfilaments. Staiger, C.J., Yuan, M., Valenta, R., Shaw, P.J., Warn, R.M., Lloyd, C.W. Curr. Biol. (1994)
- The three-dimensional structure of the cell wall glycoprotein of Chlorogonium elongatum. Shaw, P.J., Hills, G.J. J. Cell. Sci. (1984)
- Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides. Jardetzky, T.S., Brown, J.H., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L., Wiley, D.C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity. Khoshnan, A., Ko, J., Patterson, P.H. Proc. Natl. Acad. Sci. U.S.A. (2002)
- STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum. Bult, A., Zhao, F., Dirkx, R., Sharma, E., Lukacsi, E., Solimena, M., Naegele, J.R., Lombroso, P.J. J. Neurosci. (1996)
- The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP. Shapiro, M.J., Powell, P., Ndubuizu, A., Nzerem, C., Shapiro, V.S. J. Biol. Chem. (2004)
- Selective antibody reactivity with peptides from human endogenous retroviruses and nonviral poly(amino acids) in patients with systemic lupus erythematosus. Bengtsson, A., Blomberg, J., Nived, O., Pipkorn, R., Toth, L., Sturfelt, G. Arthritis Rheum. (1996)
- Dissecting the proline effect: dissociations of proline radicals formed by electron transfer to protonated Pro-Gly and Gly-Pro dipeptides in the gas phase. Hayakawa, S., Hashimoto, M., Matsubara, H., Turecek, F. J. Am. Chem. Soc. (2007)
- Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity. Ball, L.J., Kühne, R., Hoffmann, B., Häfner, A., Schmieder, P., Volkmer-Engert, R., Hof, M., Wahl, M., Schneider-Mergener, J., Walter, U., Oschkinat, H., Jarchau, T. EMBO J. (2000)
- Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Tang, Y., Hu, L.A., Miller, W.E., Ringstad, N., Hall, R.A., Pitcher, J.A., DeCamilli, P., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (1999)
- A role for the polyproline domain of p53 in its regulation by Mdm2. Berger, M., Vogt Sionov, R., Levine, A.J., Haupt, Y. J. Biol. Chem. (2001)
- CD80 binding polyproline helical peptide inhibits T cell activation. Srinivasan, M., Lu, D., Eri, R., Brand, D.D., Haque, A., Blum, J.S. J. Biol. Chem. (2005)
- The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells. Dang, A., Frost, J.A., Cobb, M.H. J. Biol. Chem. (1998)
- Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides. Mattiuzzo, M., Bandiera, A., Gennaro, R., Benincasa, M., Pacor, S., Antcheva, N., Scocchi, M. Mol. Microbiol. (2007)
- SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage. Anas, M.K., Lee, M.B., Zhou, C., Hammer, M.A., Slow, S., Karmouch, J., Liu, X.J., Bröer, S., Lever, M., Baltz, J.M. Development (2008)
- Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. Helaakoski, T., Annunen, P., Vuori, K., MacNeil, I.A., Pihlajaniemi, T., Kivirikko, K.I. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Polyproline II structure in a sequence of seven alanine residues. Shi, Z., Olson, C.A., Rose, G.D., Baldwin, R.L., Kallenbach, N.R. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Circular dichroism and nuclear magnetic resonance spectroscopic analysis of immunogenic gluten peptides and their analogs. Parrot, I., Huang, P.C., Khosla, C. J. Biol. Chem. (2002)
- Comparative vibrational spectroscopy of intracellular tau and extracellular collagen I reveals parallels of gelation and fibrillar structure. Juszczak, L.J. J. Biol. Chem. (2004)
- Profilin is predominantly associated with monomeric actin in Acanthamoeba. Kaiser, D.A., Vinson, V.K., Murphy, D.B., Pollard, T.D. J. Cell. Sci. (1999)