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Gene Review

PFN2  -  profilin 2

Homo sapiens

Synonyms: D3S1319E, PFL, Profilin II, Profilin-2
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Disease relevance of PFN2


High impact information on PFN2


Chemical compound and disease context of PFN2


Biological context of PFN2

  • The putative mouse homolog of PFN2 was mapped to mouse chromosome 3, thus suggesting a localization for the mouse homolog of USH3 [11].
  • RESULTS: In the first cycle of PFL chemotherapy, GM-CSF significantly reduced the incidence, mean duration, and mean area under the curve (AUC) of severe oral gross mucositis (grade > or = 3) compared with no therapy [4].
  • In the early stage, downregulation of collagens and keratins, together with upregulation of profilin 2 and ICAM-2, suggested cytoskeletal changes and cell adhesion remodeling [12].
  • The objectives of this study were to establish the maximum tolerated dose of vinorelbine in combination with PFL, and to define the overall response rate in a cohort of patients treated with the maximum tolerated dose [13].
  • In the present study, leachates of solid wastes from a polyfiber factory (PFL), an aeronautical plant (AEL), and a municipal sludge leachate (MSL) were assessed for their ability to induce DNA damage in human peripheral blood lymphocytes using the alkaline Comet assay [14].

Anatomical context of PFN2


Associations of PFN2 with chemical compounds


Other interactions of PFN2

  • The 115 differences detected again emphasized the abundance of neurons in the olfactory organ, especially a cluster of mRNAs encoding cytoskeletal-associated proteins and cell adhesion molecules such as 14-3-3zeta, actins, tubulins, trophinin, Fax, Yel077cp, suppressor of profilin 2, and gelsolin [22].

Analytical, diagnostic and therapeutic context of PFN2


  1. Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. Vokes, E.E., Weichselbaum, R.R., Mick, R., McEvilly, J.M., Haraf, D.J., Panje, W.R. J. Natl. Cancer Inst. (1992) [Pubmed]
  2. Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck. Dreyfuss, A.I., Clark, J.R., Wright, J.E., Norris, C.M., Busse, P.M., Lucarini, J.W., Fallon, B.G., Casey, D., Andersen, J.W., Klein, R. Ann. Intern. Med. (1990) [Pubmed]
  3. Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for squamous cell carcinoma of the head and neck: long-term results. Clark, J.R., Busse, P.M., Norris, C.M., Andersen, J.W., Dreyfuss, A.I., Rossi, R.M., Poulin, M.D., Colevas, A.D., Tishler, R.B., Costello, R., Lucarini, J.W., Lucarini, D., Thornhill, L., Lackey, M., Peters, E., Posner, M.R. J. Clin. Oncol. (1997) [Pubmed]
  4. Effect of granulocyte-macrophage colony-stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy. Chi, K.H., Chen, C.H., Chan, W.K., Chow, K.C., Chen, S.Y., Yen, S.H., Chao, J.Y., Chang, C.Y., Chen, K.Y. J. Clin. Oncol. (1995) [Pubmed]
  5. In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. Witke, W., Podtelejnikov, A.V., Di Nardo, A., Sutherland, J.D., Gurniak, C.B., Dotti, C., Mann, M. EMBO J. (1998) [Pubmed]
  6. X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates. Fedorov, A.A., Magnus, K.A., Graupe, M.H., Lattman, E.E., Pollard, T.D., Almo, S.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for locally advanced head and neck cancer: a clinical and pharmacologic analysis. Vokes, E.E., Schilsky, R.L., Weichselbaum, R.R., Kozloff, M.F., Panje, W.R. J. Clin. Oncol. (1990) [Pubmed]
  8. Neoadjuvant PFL augmented by methotrexate and piritrexim followed by concomitant chemoradiotherapy for advanced head and neck cancer: a feasible and active approach. Vokes, E.E., Haraf, D.J., McEvilly, J.M., Mick, R., Kozloff, M.F., Goldman, M.D., Moran, W.J., Clendeninn, N.J., Collier, M.A., Weichselbaum, R.R. Ann. Oncol. (1992) [Pubmed]
  9. Primary site management following induction chemotherapy with cis-platinum, 5-fluorouracil, and leucovorin. Busse, P.M., Clark, J.R., Beard, C.J., Dreyfuss, A.I., Lucarini, J.W., Rossi, R., Casey, D., Norris, C.M. Head & neck. (1993) [Pubmed]
  10. Cisplatin, fluorouracil, and L-leucovorin induction chemotherapy for locally advanced head and neck cancer: the M.D. Anderson Cancer Center experience. Papadimitrakopoulou, V.A., Dimery, I.W., Lee, J.J., Perez, C., Hong, W.K., Lippman, S.M. The cancer journal from Scientific American. (1997) [Pubmed]
  11. Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region. Joensuu, T., Blanco, G., Pakarinen, L., Sistonen, P., Kääriäinen, H., Brown, S., Chapelle, A., Sankila, E.M. Genomics (1996) [Pubmed]
  12. Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Schmidt, W.M., Kalipciyan, M., Dornstauder, E., Rizovski, B., Steger, G.G., Sedivy, R., Mueller, M.W., Mader, R.M. Int. J. Cancer (2004) [Pubmed]
  13. A phase II study of cisplatin, 5-fluorouracil, and leucovorin augmented by vinorelbine (Navelbine) for advanced non-small cell lung cancer: rationale and study design. Vokes, E.E., Drinkard, L.C., Samuels, B.L., Hoffman, P.C., Watson, S., Bitran, J.D., Haraf, D.J., Ferguson, M.F., Golomb, H.M. Semin. Oncol. (1994) [Pubmed]
  14. DNA damage induced in human peripheral blood lymphocytes by industrial solid waste and municipal sludge leachates. Bakare, A.A., Pandey, A.K., Bajpayee, M., Bhargav, D., Chowdhuri, D.K., Singh, K.P., Murthy, R.C., Dhawan, A. Environ. Mol. Mutagen. (2007) [Pubmed]
  15. Cloning and expression of a novel human profilin variant, profilin II. Honoré, B., Madsen, P., Andersen, A.H., Leffers, H. FEBS Lett. (1993) [Pubmed]
  16. Leukotriene C4 ([3H]-LTC4) binding to membranes isolated from a hamster smooth muscle cell line (DDT1MF2). Clark, M.A., Cook, M., Mong, S., Hogaboom, G.K., Shorr, R., Stadel, J., Crooke, S.T. Life Sci. (1984) [Pubmed]
  17. Management for patients with advanced T4 epidermoid carcinoma of the esophagus. Wang, L.S., Chi, K.H., Hu, M.H., Fahn, H.J., Huang, M.H. Journal of surgical oncology. (1996) [Pubmed]
  18. X-ray structure determination of human profilin II: A comparative structural analysis of human profilins. Nodelman, I.M., Bowman, G.D., Lindberg, U., Schutt, C.E. J. Mol. Biol. (1999) [Pubmed]
  19. Profilin is predominantly associated with monomeric actin in Acanthamoeba. Kaiser, D.A., Vinson, V.K., Murphy, D.B., Pollard, T.D. J. Cell. Sci. (1999) [Pubmed]
  20. Distinct biochemical characteristics of the two human profilin isoforms. Gieselmann, R., Kwiatkowski, D.J., Janmey, P.A., Witke, W. Eur. J. Biochem. (1995) [Pubmed]
  21. Cisplatin, fluorouracil, and leucovorin induction chemotherapy followed by concurrent cisplatin chemoradiotherapy for organ preservation and cure in patients with advanced head and neck cancer: long-term follow-up. Psyrri, A., Kwong, M., DiStasio, S., Lekakis, L., Kassar, M., Sasaki, C., Wilson, L.D., Haffty, B.G., Son, Y.H., Ross, D.A., Weinberger, P.M., Chung, G.G., Zelterman, D., Burtness, B.A., Cooper, D.L. J. Clin. Oncol. (2004) [Pubmed]
  22. Gene expression and specificity in the mature zone of the lobster olfactory organ. Stepanyan, R., Day, K., Urban, J., Hardin, D.L., Shetty, R.S., Derby, C.D., Ache, B.W., McClintock, T.S. Physiol. Genomics (2006) [Pubmed]
  23. Primary chemotherapy followed by anterior craniofacial resection and radiotherapy for paranasal cancer. Licitra, L., Locati, L.D., Cavina, R., Garassino, I., Mattavelli, F., Pizzi, N., Quattrone, P., Valagussa, P., Gianni, L., Bonadonna, G., Solero, C.L., Cantu, G. Ann. Oncol. (2003) [Pubmed]
  24. Outpatient weekly 24-hour infusional adjuvant chemotherapy of cisplatin, 5-fluorouracil, and leucovorin for high-risk nasopharyngeal carcinoma. Lin, J.C., Jan, J.S., Chen, K.Y., Hsu, C.Y., Liang, W.M., Wang, W.Y. Head & neck. (2003) [Pubmed]
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