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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BRWD1  -  bromodomain and WD repeat domain containing 1

Homo sapiens

Synonyms: Bromodomain and WD repeat-containing protein 1, C21orf107, FLJ11315, N143, WD repeat-containing protein 9, ...
 
 
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Disease relevance of BRWD1

 

High impact information on BRWD1

  • On mAb D120, the cells contain radial actin spikes characteristic of filopodial extension, whereas on mAb N143, the cells contain cortical actin bundles characteristic of lamellipodia [2].
  • We further show that WDR9 is a nuclear protein associated with BRG1, a SWI/SNF complex component [1].
  • We propose that WDR9 is a transcriptional regulator involved in chromatin remodeling through the action of two bromodomains and contacts to the SWI/SNF complex [1].
  • Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21 [3].
 

Biological context of BRWD1

  • Formation of lamellipodia on the N143-coated surfaces is also inhibited by transfection of the dominant negative CasdeltaSD construct [4].

References

  1. Expression of the Wdr9 gene and protein products during mouse development. Huang, H., Rambaldi, I., Daniels, E., Featherstone, M. Dev. Dyn. (2003) [Pubmed]
  2. Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration. Fang, X., Burg, M.A., Barritt, D., Dahlin-Huppe, K., Nishiyama, A., Stallcup, W.B. Mol. Biol. Cell (1999) [Pubmed]
  3. Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21. Ramos, V.C., Vidal-Taboada, J., Bergoñon, S., Egeo, A., Fisher, E.M., Scartezzini, P., Oliva, R. Biochim. Biophys. Acta (2002) [Pubmed]
  4. Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas. Majumdar, M., Vuori, K., Stallcup, W.B. Cell. Signal. (2003) [Pubmed]
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